柴胡-黄芩调控中枢神经系统功能研究进展  

Research Progress in Regulation of Central Nervous System Function by Radix Bupleuri and Scutellaria Baicalensis

作　　者：李晨阳 赵姣娇 张炜 LI Chen-yang;ZHAO Jiao-jiao;ZHANG Wei(Institute of Integrated Traditional Chinese and Western Medicine,Hebei Medical University,Shijiazhuang,050017,China)

机构地区：[1]河北医科大学中西医结合研究所,石家庄050017

出　　处：《神经药理学报》2022年第4期49-57,共9页Acta Neuropharmacologica

基　　金：国家自然科学基金资助项目(No.81872848)。

摘　　要：柴胡与黄芩是古代方剂中常见的药对配伍,在很多著名古方中均有记载。现代药理研究表明柴胡-黄芩在防治癫痫、抑郁、阿尔茨海默症、脑胶质瘤、脑缺血再灌注等方面表现出良好的效果,其机制为通过调控神经细胞信号通路、炎症因子水平、细胞凋亡过程、神经递质含量等机制发挥防治中枢神经系统疾病的作用,且两药配伍对神经保护具有协同作用,该文综述了国内外学者对柴胡-黄芩及其化学成分防治中枢神经系统疾病的相关研究,旨在为更好地研究开发和合理利用两种药物提供参考。The compatibility of Radix Bupleuri and Scutellaria Baicalensis was common in ancient prescriptions and was recorded in many famous ancient prescriptions.Modern pharmacological studies showed that the combination of Radix Bupleuri and Scutellaria Baicalensis had good effects on the prevention and treatment of epilepsy,depression,Alzheimer’s disease,glioma,and cerebral ischemia-reperfusion.The combination of the two drugs synergistically protected nerves and played a role in the prevention and treatment of central nervous system diseases by regulating nerve cell signaling pathways,inflammatory factor level,cell apoptosis process,neurotransmitter content,and other mechanisms.In this paper,the domestic and foreign research on the prevention and treatment of central nervous system diseases by Radix Bupleuri-Scutellaria baicalensis and its chemical components were reviewed,aiming to provide a reference for better research and development and rational utilization of the two drugs.

关 键 词：柴胡 黄芩 炎症 凋亡 信号通路 中枢神经系统 

分 类 号：R969[医药卫生—药理学]