免疫球蛋白超家族8及其翻译后修饰研究进展  

IgSF8 and its post-translational modifications

作　　者：张可 李旭[2] 王妍 ZHANG Ke;LI Xu;WANG Yan(Institute of Military Cognition and Brain Science,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China;The First Hospital of China Medical University,Shenyang 110000,China)

机构地区：[1]军事科学院军事医学研究院军事认知与脑科学研究所,北京100850 [2]中国医科大学附属第一医院,沈阳110000

出　　处：《军事医学》2023年第3期236-239,F0003,共5页Military Medical Sciences

基　　金：国家重点研发计划资助项目(2016YFE0204400)。

摘　　要：免疫球蛋白超家族8(IgSF8)是IgSF成员之一,其胞内短尾结构域与细胞的多种生物学效应存在较强的相关性。棕榈酰化和糖基化是IgSF8分子主要的蛋白质翻译后修饰形式。IgSF8和CD9的棕榈酰化可能对二者的异源聚合体形成以及发挥生物学功能起支持作用。近年来的多项研究表明,IgSF8在细胞增殖、细胞迁移和神经系统发育等多种生物学进程中扮演重要角色。该文主要对IgSF8的分子特征和翻译后修饰方面的研究进展进行综述,旨在为解析IgSF8的生物学功能提供研究思路。Immunoglobulin superfamily 8(IgSF8)is one member of the IgSF,and intracellular short-tail motif of IgSF8molecule has a strong correlation with many biological effects.Palmitoylation and glycosylation,two of the main posttranslational modification forms of IgSF8 and CD9,may play a fundamental role in the formation of heteropolymers and their biological functions.In recent years,a number of studies have shown that IgSF8 is of great significance in many biological processes,such as cell proliferation,cell migration and development of the nervous system.This article focuses on the research progress in IgSF8 molecular characteristics and post-translational modification,and proposes future areas of study on IgSF8.

关 键 词：免疫球蛋白超家族8 棕榈酰化 糖基化 四跨膜蛋白超家族 

分 类 号：R392[医药卫生—免疫学]