sPD-1和sPD-Ls在结缔组织病发病机制中的作用  

Role of sPD-1 and sPD-Ls in the pathogenesis of connective tissue disease

作　　者：何豪华 何晓宇 周明骏 汤迎凯 代丽 谢卓贝 王元元[4,5] 谢长好[1,6] HE Haohua;HE Xiaoyu;ZHOU Mingjun;TANG Yingkai;DAI Li;XIE Zhuobei;WANG Yuanyuan;XIE Changhao(Department of Rheumatology and Immunology,First Affiliated Hospital of Bengbu Medical College,Bengbu Anbui 233099;Department of Clinical Medicine,Bengbu Medical College,Bengbu Anbui 233030;Department of Human Anatomy,Bengbu Medical College,Bengbu Anbui 233030;Department of Histology and Embryology,Bengbu Medical College,Bengbu Anbui 233030;Micromorphology Experiment Center,Bengbu Medical College,Bengbu Anbui 233030;Anhui Province Key Laboratory of Immunology in Chronic Diseases,Bengbu Medical College,Bengbu Anbui 233030,China)

机构地区：[1]蚌埠医学院第一附属医院风湿免疫科,安徽蚌埠233099 [2]蚌埠医学院临床医学系,安徽蚌埠233030 [3]蚌埠医学院人体解剖学教研室,安徽蚌埠233030 [4]蚌埠医学院组织学与胚胎学教研室,安徽蚌埠233030 [5]蚌埠医学院显微形态实验中心,安徽蚌埠233030 [6]蚌埠医学院慢性疾病免疫学基础与临床安徽省重点实验室,安徽蚌埠233030

出　　处：《中南大学学报（医学版）》2023年第3期444-454,共11页Journal of Central South University ：Medical Science

基　　金：安徽省自然科学基金(2108085MH258);安徽高校自然科学研究重点项目(KJ2021A0763);蚌埠医学院转化医学重点项目(BYTM2019003);蚌埠医学院研究生科研创新计划(Byycx22028,Byycx21064,Byycxz21093)。

摘　　要：膜结合型程序性死亡受体1(membrane-bound programmed cell death-1,mPD-1)及膜结合型程序性死亡受体配体(membrane-bound programmed cell death-ligands,mPD-Ls)存在可溶性形式,分别为可溶性程序性死亡受体1(soluble programmed cell death-1,sPD-1)和可溶性程序性死亡受体配体(soluble programmed cell death-ligands,sPD-Ls)[包括可溶性程序性死亡受体配体1(soluble programmed cell death-ligand 1,sPD-L1)和可溶性程序性死亡受体配体2(soluble programmed cell death-ligand 2,sPD-L2)]。sPD-1和sPD-L2主要由PD-1 mRNA的选择性剪接异构体翻译产生,而sPD-L1则是由基质金属蛋白酶(matrix metalloproteinases,MMPs)剪切膜结合型程序性死亡受体配体1(membrane-bound programmed cell death-ligand 1,mPD-L1)产生。sPD-1和sPD-Ls通过阻断mPD-1/mPD-L1通路在自身免疫调节中起重要作用,而结缔组织病(connective tissue disease,CTD)是由自身免疫反应等引起的一类疾病,并且多种自身免疫性疾病在发生、发展过程中均可出现mPD-1/mPD-L1的功能异常。故sPD-1和sPD-Ls通过阻断mPD-1/mPD-L1通路,在由自身免疫反应引起的CTD发病机制中起重要作用。了解sPD-1和sPD-Ls在CTD中的作用机制和临床价值对改善患者的生活质量具有重要的现实意义。Membrane-bound programmed cell death-1(mPD-1)and membrane-bound programmed cell death-ligands(mPD-Ls)have soluble forms,which are soluble programmed cell death-1(sPD-1)and soluble programmed cell death-ligands(sPD-Ls)[including soluble programmed cell death-ligand 1(sPD-L1)and soluble programmed cell death-ligand 2(sPD-L2)].sPD-1 and sPD-L2 are mainly produced by alternative splicing isoforms of PD-1 mRNA,while sPD-L1 is produced by matrix metalloproteinases(MMPs)cutting membrane-bound programmed cell death-ligand 1(mPD-L1).sPD-1 and sPD-Ls play an important role in autoimmune regulation via blocking the mPD-1/mPD-L1 pathway,while connective tissue disease(CTD)is a kind of disease caused by autoimmune reaction,and abnormal function of mPD-1/mPD-L1 can occur in the occurrence and development of many autoimmune diseases.Therefore,sPD-1 and sPD-Ls play an important role in the pathogenesis of CTD caused by autoimmune reaction via blocking the mPD-1/mPD-L1 pathway.It is of great practical significance to understand clinical value of sPD-1 and sPDLs in various CTDs for improving the quality of life of patients and the underlying mechanism.

关 键 词：可溶性程序性死亡受体1 可溶性程序性死亡受体配体 结缔组织病 发病机制 

分 类 号：R593.2[医药卫生—内科学]