基于体检资料的高尿酸血症患病现状及危险因素  

Prevalence and Risk Factors of Hyperuricemia based on Physical Examination Data

作　　者：张艺潆 张换想 刘志玄 邱洪斌 ZHANG Yiying;ZHANG Huanxiang;LIU Zhixuan(Department of Epidemiology and Biostatistics,School of Public Health,Jiamusi University,Heilongjiang 154007,China)

机构地区：[1]佳木斯大学公共卫生学院流行病与卫生统计学教研室,154007

出　　处：《医学研究杂志》2023年第4期73-77,共5页Journal of Medical Research

基　　金：黑龙江省自然科学基金优秀青年项目(YQ2019H032)。

摘　　要：目的 通过流行病学调查,探索高尿酸血症患病的危险因素,为科学防控高尿酸血症提供依据。方法 本研究采用横断面调查方法,从国家人口健康科学数据中心选取2010~2013年在北京协和医院参加年度体检的国家机关和事业单位人群作为研究对象。采用t检验、χ2检验、多因素逐步Logistic回归分析评估不同性别高尿酸血症发生的危险因素。结果 共纳入参与者1401例,其中男性876例,女性525例。在男性中,脂肪肝(OR=2.196,95%CI:1.282~3.760)、体重指数(OR=1.091,95%CI:1.012~1.177)、高甘油三酯(OR=1.658,95%CI:1.077~2.551)是高尿酸血症的独立危险因素;在女性中,脂肪肝(OR=3.715,95%CI:1.494~9.241)和高甘油三酯(OR=2.604,95%CI:1.114~6.086)是高尿酸血症的危险因素。结论 脂肪肝、体重指数增高、高甘油三酯的人群更易患高尿酸血症。建议通过合理饮食,适度运动,控制体重指数、甘油三酯等危险因素以改善人体血尿酸水平,预防高尿酸血症的发生。Objective To explore the risk factors of hyperuricemia through epidemiological investigation,and provide evidence for scientific prevention and control of hyperuricemia.Methods A cross-sectional survey was conducted in this study.Participants were selected from the National Population Health Data Center(NPDC),who participated in annual physical examination in Peking Union Medical College Hospital from 2010 to 2013.t test,χ2 test and multiple Logistic regression was used to analysis the risk factors of hyperuricemia in different genders.Results 1401 participants were enrolled,including 876males and 525 females.In males,fatty liver(OR=2.196,95%CI:1.282-3.760),body mass index(OR=1.091,95%CI:1.012-1.177),and high triglyceride(OR=1.658,95%CI:1.077-2.551)were independent risk factors of hyperuricemia.In females,fatty liver(OR=3.715,95%CI:1.494-9.241)and high triglyceride(OR=2.604,95%CI:1.114-6.086)were risk factors of hyperuricemia.Conclusion People with fatty liver,increased body mass index and high triglyceride are more likely to develop hyperuricemia.It is suggested to improve human blood uric acid level and prevent hyperuricemia through reasonable diet,moderate exercise,control of body mass index,triglyceride and other risk factors.

关 键 词：高尿酸血症 横断面研究 危险因素 

分 类 号：R589[医药卫生—内分泌]