基于双中心数据挖掘的2型糖尿病肾病患者降糖药物应用现状及合理性分析  

Application Status and Rationality Analysis of Hypoglycemic Drugs in Patients with Type 2 Diabetic Nephropathy Based on Two-center Data Mining

作　　者：樊金梦 韩笑 刘沛 刘则坤 齐昊[2] FAN Jinmeng;HAN Xiao;LIU Pei(Shanxi Medical University,Shanxi 030000,China)

机构地区：[1]山西医科大学,太原030000 [2]山西医科大学第一医院内分泌科,太原030000

出　　处：《医学研究杂志》2023年第4期78-82,共5页Journal of Medical Research

基　　金：山西省重点研发计划项目(201803D31099)。

摘　　要：目的 探讨两所三甲综合医院的2型糖尿病肾病患者降糖药物应用现状并分析用药是否合理。方法 利用医疗大数据平台检索两所医院2018年1月1日~2021年1月31日于内分泌科与肾内科住院的2型糖尿病肾病患者,利用频数、频率、关联规则分析等数据挖掘方法对患者降糖药物应用现状及合理性进行分析。结果 根据临床资料,频率分析显示,2型糖尿病肾病患者首选胰岛素治疗,α-糖苷酶抑制剂与双胍类次之;对联合用药分析显示,胰岛素与双胍类、α-糖苷酶抑制剂关联性较强;根据患者eGFR水平,结合临床指南对用药情况评估显示部分患者的用药存在不合理,未合理使用的药物主要为二甲双胍与阿卡波糖。结论 两所三甲综合医院降糖药物使用频率较高的为传统降糖药物,用药存在少数不合理情况,呼吁临床遵循指南合理用药。Objective To investigate the application status of antidiabetic drugs in type 2diabetic nephropathy in two grade 3A general hospitals and evaluate the rationality of medication.Methods The data of the patients with type 2diabetic nephropathy hospitalized in Department of Endocrinology and Nephrology of two grade 3A hospitals from January 1 st,2018 to January 31 th,2021 on the medical big data platform of the two hospitals and data mining methods such as frequency and association rule analysis were used to analyze the application status and rationality of antiglycemic drugs in the patients.Results According to the clinical data,frequency analysis showed that insulin was the first choice for patients with type 2diabetic nephropathy,followed byα-glycosidase inhibitors and biguanides.Analysis of combination drugs showed that insulin had a strong correlation with biguanides andα-glycosidase inhibitors.Unreasonable drug uses were found in some patients according to their eGFR levels and the clinical guidelines,and the main drugs were metformin and acarbose.Conclusion Traditional antidiabetic drugs were frequently used in two grade 3A general hospitals,and there were a few unreasonable cases in them,which call for clinical rational drug use according to the guidelines.

关 键 词：糖尿病肾病 降糖药物 合理用药 数据挖掘 

分 类 号：R587[医药卫生—内分泌]