A study of efficacy of Nigella sativa in treatment of Meniere's disease: A randomized, placebo controlled clinical trial  

作　　者：Masoud Motesadi Zarandi Zahra Rabbani Mahtab Rabbani Anari Ali Kouhi Mona Zeinaloo 

机构地区：[1]Department of Cochlear Implant and Otorhinolaryngology,Tehran University of Medical Sciences,Tehran,Iran [2]Amir Alam Hospital,Tehran University of Medical Sciences,Tehran,Iran [3]Otorhinolaryngology Research Center,Amir Alam Hospital,Tehran University of Medical Sciences,Tehran,Iran [4]Otorhinolaryngology Research Center,Tehran University of Medical Sciences,Tehran,Iran [5]Department of Otorhinolaryngology and Head and Neck Surgery,Amir Alam Hospital,Tehran University of Medical Sciences,Tehran,Iran [6]Department of Community Medicine,Tehran University of Medical Sciences,Tehran,Iran

出　　处：《Journal of Otology》2023年第2期97-100,共4页中华耳科学杂志（英文版）

摘　　要：Purpose:Meniere's disease(MD),first introduced by Prosper Meniere,is characterized mainly by vertigo,tinnitus,aural fullness and sensorineural hearing loss.Though the exact pathophysiology of MD is unknown,immunologic and inflammatory interactions are possible underlying mechanisms involved in MD.This study is aimed to investigate the immunomodulatory and anti-inflammatory effect of Nigella sativa on MD as a therapeutic agent.Methods:We divided 40 patients with definite MD into two groups of 20 cases.The study group received 1 g of Nigella sativa oil daily for three months and the control group received a placebo.Changes in hearing,tinnitus and vertigo were estimated by pure tone audiometry,tinnitus handicap inventory questionnaire and dizziness handicap inventory questionnaire,respectively.Results:At the end of the study we did not observe any significant improvement in study's group hearing threshold,tinnitus and vertigo compared to the control group.Conclusions:In this study,statistical analysis showed that Nigella sativa failed to improve signs and symptoms of MD.However,further investigations with a larger study population are needed to ascertain the current conclusion.

关 键 词：Meniere's disease Nigella sativa TINNITUS VERTIGO Hearing loss 

分 类 号：R764.33[医药卫生—耳鼻咽喉科]