ET-1、MMP-9、HB-EGF水平变化对ACS患者PCI术后预后的预测价值  

Predictive value of changes in ET-1,MMP-9 and HB-EGF levels on the prognosis of ACS patients after PCI

作　　者：唐庆业 陈世雄 陈清华 张兴建 TANG Qingye;CHEN Shixiong;CHEN Qinghua;ZHANG Xingjian(Department of Cardiovascular Medicine,Danzhou People′s Hospital,Danzhou,Hainan 571700,China)

机构地区：[1]儋州市人民医院心血管内科,海南儋州571700

出　　处：《国际检验医学杂志》2023年第9期1116-1120,共5页International Journal of Laboratory Medicine

基　　金：海南省医药卫生科研项目(2001320114A2009)。

摘　　要：目的探讨内皮素-1(ET-1)、基质金属蛋白酶-9(MMP-9)、肝素结合性表皮生长因子(HB-EGF)水平变化对急性冠脉综合征(ACS)患者经皮冠状动脉介入治疗术(PCI)术后预后的预测价值。方法选取2020年5月至2021年5月该院收治并进行PCI的150例ACS患者为研究对象。分析PCI术后不同预后ACS患者ET-1、MMP-9、HB-EGF水平,分析各指标与预后不良的相关性,以及预后不良的危险因素,分析其对ACS患者PCI术后随访6个月内预后情况的预测价值。结果随访期间,150例患者中预后良好119例,预后不良31例;预后不良组ET-1、MMP-9、HB-EGF水平均高于预后良好组(P<0.05),三支血管病变者占比高于预后良好组(P<0.05),左室射血分数(LVEF)低于预后良好组(P<0.05)。血管病变支数及ET-1、MMP-9、HB-EGF与预后不良呈正相关(P<0.05),多支数血管病变及ET-1、MMP-9、HB-EGF水平高是影响患者预后不良的危险因素(P<0.05)。ET-1、MMP-9、HB-EGF联合预测ACS患者PCI术后6个月内预后的曲线下面积高于单项检测(P<0.05)。结论PCI术后预后不良ACS患者ET-1、MMP-9、HB-EGF呈高表达水平,上述指标联合检测对ACS患者PCI术后预后具有一定预测价值。Objective To investigate the predictive value of changes in endothelin-1(ET-1),matrix metalloproteinase-9(MMP-9)and heparin-binding epidermal growth factor(HB-EGF)levels on the prognosis of acute coronary syndrome(ACS)patients after percutaneous coronary intervention(PCI).Methods The correlation between poor prognosis and each index and the factors of poor prognosis,predictive value.A total of 150 patients with ACS who underwent PCI in this hospital from May 2020 to May 2021 were selected as the study objects.The levels of ET-1,MMP-9 and HB-EGF in ACS patients with different prognosis after PCI were analyzed,and the correlation between each indicator and poor prognosis,as well as the risk factors of poor prognosis were analyzed.Meannwhile,the predictive value of these indicators for the prognosis of ACS patients after PCI in the follow-up 6 months was analyzed.Results During the follow-up period,119 of the 150 patients had good prognosis and 31 had poor prognosis.The levels of ET-1,MMP-9 and HB-EGF in poor prognosis group were higher than those in good prognosis group(P<0.05),the proportion of patients with three vessel lesions was higher than that in good prognosis group(P<0.05),and LVEF was lower than that in good prognosis group(P<0.05).The number of vascular lesions and ET-1,MMP-9,HB-EGF were positively correlated with poor prognosis(P<0.05).Besides,the number of vascular lesions and high levels of ET-1,MMP-9,HB-EGF were risk factors for poor prognosis(P<0.05).The area under the curve of ET-1,MMP-9 and HB-EGF combined in predicting the prognosis of ACS patients after PCI within 6 months was higher than that of single test(P<0.05).Conclusion ACS patients with poor prognosis after PCI usually show high expression levels of ET-1,MMP-9 and HB-EGF,and the combined detection of these indexes has certain predictive value for the prognosis of ACS patients after PCI.

关 键 词：急性冠脉综合征 经皮冠状动脉介入 内皮素-1 基质金属蛋白酶-9 肝素结合性表皮生长因子 预后 

分 类 号：R446.11[医药卫生—诊断学] R743.3[医药卫生—临床医学]