全氟化碳纳米乳在肿瘤诊疗中的研究进展  

Research Progress of Perfluorocarbon Nanoemulsion in Tumor Diagnosis and Treatment

作　　者：刘灿 陈沁颖 吴彦萍 涂家生[1] 孙春萌[1] LIU Can;CHEN Qinying;WU Yanping;TU Jiasheng;SUN Chunmeng(NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients,Center for Research Development and Evaluation of Pharmaceutical Excipients and Generic Drugs,School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]国家药品监督管理局药物制剂及辅料研究与评价重点实验室,中国药科大学药用辅料及仿创药物研发评价中心,中国药科大学药学院,南京210009

出　　处：《药学与临床研究》2023年第2期153-158,184,共7页Pharmaceutical and Clinical Research

基　　金：国家自然科学基金项目(22278442;81972894)

摘　　要：全氟化碳(PFC)纳米乳广泛应用于肿瘤的诊疗中,其PFC核心不仅能向肿瘤环境递送氧气,缓解肿瘤微环境缺氧状态,提高氧依赖性治疗方式的疗效,同时也可以在高能量的激发下发生从气态到液态的转变,应用于肿瘤成像和药物递送。本文综述了PFC纳米乳在肿瘤治疗和诊断中的研究进展,系统总结了PFC纳米乳分类以及在肿瘤治疗和诊断方面的应用,并提出了目前仍存在的一些问题及未来的研究方向。Perfluorocarbon(PFC)nanoemulsionis is widely used in the diagnosis and treatment of tumors.The PFC core can not only deliver oxygen to the tumor environment,alleviate the hypoxia state of the tumor microenvironment and improve the efficacy of oxygen-dependent treatment,but also undergo the transformation from gaseous to liquid state under high-energy excitation,which can be applied to tumor imaging and drug delivery.In this review,we focus on the research progress of perfluorocarbon nanoemulsion in tumor treatment and diagnosis,systematically summarize its classification and application in tumor diagnosis and treatment,and put forward some existing problems and future research directions.

关 键 词：全氟化碳 纳米乳 肿瘤 诊疗 

分 类 号：R944[医药卫生—药剂学]