氨甲环酸的不良反应及处理  

Adverse reactions and management of tranexamic acid

作　　者：张晓丽 葛一平[1] 杨荷丹 杨寅[1] 李新宇[2] 林彤[3] ZHANG Xiaoli;GE Yiping;YANG Hedan;YANG Yin;LI Xinyu;LIN Tong(Laser Department,Institute of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042,China;Pharmacal Research laboratory,Institute of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042,China;Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs,Institute of Dermatology,Chinese Academy of Medical Sciences&Peking Union Medical College,Nanjing 210042,China)

机构地区：[1]中国医学科学院北京协和医学院皮肤病研究所激光科,南京210042 [2]中国医学科学院北京协和医学院皮肤病研究所药物研究室,南京210042 [3]中国医学科学院北京协和医学院皮肤病研究所、江苏省皮肤病与性病分子生物学重点实验室,南京210042

出　　处：《中国麻风皮肤病杂志》2023年第5期387-390,共4页China Journal of Leprosy and Skin Diseases

基　　金：国家自然科学基金资助项目(编号:82103705);中国医学科学院医学与健康科技创新工程项目(编号:CIFMS-2021-I2M-1-001)。

摘　　要：近年来氨甲环酸在皮肤科的应用日益增加,该药以低剂量口服为主,安全性较好,最常见的不良反应是胃肠道不适和月经不规则。但长期系统应用氨甲环酸可导致多种不良反应,如血栓形成、肝肾功能损害、视力缺陷等。因此,长期服用氨甲环酸时需定期监测凝血功能、D-二聚体、肝肾功能等相关指标,争取及时发现并尽快处理药物不良反应,保证用药安全。Tranexamic acid has been increasingly used in dermatology in recent years.The drug is mainly administrated orally at low doses with good safety,and the most common adverse reactions are gastrointestinal discomfort and menstrual irregularity.However,long-term systemic application of tranexamic acid can lead to a variety of adverse reactions,such as thrombosis,hepatic and kidney impairment,visual defects,etc.Therefore,regularly monitoring blood coagulation function,D-dimer,hepatic and kidney function and other related indicators is necessary when taking tranexamic acid for a long time,so as to detect and manage adverse reactions timely and ensure drug safety.

关 键 词：氨甲环酸 不良反应 血栓形成 处理 

分 类 号：R973.1[医药卫生—药品]