Recent Developments in Copper(Ⅰ)-Catalyzed Enantioselective Alkynylation Reactions via a Radical Process  

作　　者：Xueling Mo Rui Guo Guozhu Zhang 

机构地区：[1]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Center for Excellence in Molecular Synthesis,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai,200032 China [2]CCNU-uOttawa Joint Research Centre,Key Laboratory of Pesticides&Chemical Biology Ministry of Education,International Joint Research Center for Intelligent Biosensing Technology and Health,College of Chemistry,Central China Normal University(CCNU),Wuhan,Hubei,430079 China

出　　处：《Chinese Journal of Chemistry》2023年第4期481-489,共9页中国化学（英文版）

基　　金：We are grateful to the National Natural Science Foundation of China(22071073,22271112,21772218,and 21821002);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB20000000);State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences and the Central China Normal University(CCNU).

摘　　要：Alkynes are one of the most significant functional groups in organic chemistry and great efforts have been made to explore efficient approach for the construction of chiral alkynes.The asymmetric C(sp^(3))–C(sp)cross-coupling provides a significant complementary strategy through radical-initiated process.However,the stereocontrol of highly reactive and unstable radical intermediate has been a challenge for decades.To address this problem,a variety of chiral ligands are developed for initiating the reaction and achieving enantiocontrol of alkyl radicals.This review summarizes recent developments in copper-catalyzed enantioselective alkynylation of prochiral alkyl radicals and their brief mechanistic studies.

关 键 词：ALKYNYLATION Radical reactions Copper catalysis CROSS-COUPLING Asymmetric transformation Synthetic methods 

分 类 号：O621.251[理学—有机化学]