一例梅毒感染合并家族性高胆固醇血症的早发心肌梗死  

An Early Onset of Myocardial Infarction Patient with Syphilis and Familial Hypercholesterolemia

作　　者：张滨 吴炜[2,3] ZHANG Bin;WU Wei(Department of Internal Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Cardiology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院内科,北京100730 [2]中国医学科学院北京协和医院心内科,北京100730 [3]中国医学科学院北京协和医院疑难重症及罕见病国家重点实验室,北京100730

出　　处：《罕见病研究》2023年第1期85-87,共3页Journal of Rare Diseases

基　　金：中央高水平医院临床科研业务费(2022-PUMCH-B-098)。

摘　　要：梅毒感染可以引起心血管系统受累,但冠状动脉受累是较为少见的临床表现。家族性高胆固醇血症(FH)是一种因低密度脂蛋白胆固醇(LDL-C)清除障碍导致LDL-C水平显著升高,造成早发严重动脉粥样硬化的常染色体显性遗传疾病。本文报道一例梅毒感染合并FH的青年男性患者,临床表现为急性心肌梗死、高LDL-C血症,冠脉造影及腔内影像检查可见冠状动脉多发瘤样扩张和狭窄,经反复冠状动脉药物球囊扩张后短期内再狭窄,最终植入支架治疗。Syphilis may affect the cardiovascular system,in which coronary arteries are less commonly involved.Familial hypercholesterolemia(FH)is an autosomal dominant inherited disease with elevated low-density lipoprotein-cholesterol(LDL-C)levels due to impaired LDL-C clearance.We report a young male patient with syphilis and FH.The clinical manifestations were acute myocardial infarction and high LDL-C levels.Coronary angiography and intracoronary imaging showed multiple aneurysmal ectasia and stenosis.A drug-eluting stent was implemented when recurrent restenosis occurred after two percutaneous coronary drug-eluting balloon angioplasties.

关 键 词：梅毒 家族性高胆固醇血症 冠状动脉瘤样扩张 血管内超声 光学相干断层扫描 

分 类 号：R541.4[医药卫生—心血管疾病]