Altered vaginal eukaryotic virome is associated with different cervical disease status  

作　　者：Yanpeng Li Le Cao Xiao Han Yingying Ma Yanmei Liu Shujun Gao Chiyu Zhang 

机构地区：[1]Shanghai Public Health Clinical Center,Fudan University,Shanghai,201508,China [2]Center of Diagnosis and Treatment for Cervical Diseases,Obstetrics and Gynecology Hospital of Fudan University,Shanghai,200080,China [3]Shanghai Key Laboratory of Female Reproductive Endocrine-Related Disease,Fudan University,Shanghai,200080,China

出　　处：《Virologica Sinica》2023年第2期184-197,共14页中国病毒学（英文版）

基　　金：supported by the startup funding from Shanghai Public Health Clinical Center(to CZ).

摘　　要：Viruses are important components of the human body.Growing evidence suggests that they are engaged in the physiology and disease status of the host.Even though the vaginal microbiome is involved in human papillomavirus(HPV)infection and cervical cancer(CC)progression,little is known about the role of the vaginal virome.In this pilot exploratory study,using unbiased viral metagenomics,we aim to investigate the vaginal eukaryotic virome in women with different levels of cervical lesions,and examine their associations with different cervical disease status.An altered eukaryotic virome was observed in women with different levels of lesions and Lactobacillus profiles.Anelloviruses and papillomaviruses are the most commonly detected eukaryotic viruses of the vaginal virome.Higher abundance and richness of anelloviruses and papillomaviruses were associated with lowgrade squamous intraepithelial lesion(LSIL)and CC.Besides,higher anellovirus abundance was also associated with lactobacillus-depleted microbiome profiles and bacterial community state(CST)type IV.Furthermore,increased correlations between Anelloviridae and Papillomaviridae occurred in the women with increased cervical disease severity level from LSIL to CC.These data suggest underlying interactions between different microbes as well as the host physiology.Higher abundance and diversity of both anelloviruses and papillomaviruses shared by LSIL and CC suggest that anellovirus may be used as a potential adjunct biomarker to predict the risk of HPV persistent infection and/or CC.Future studies need to focus on the clinical relevance of anellovirus abundance with cervical disease status,and the evaluation of their potential as a new adjunct biomarker for the prediction and prognoses of CC.

关 键 词：Vaginal virome Cervical cancer Anellovirus PAPILLOMAVIRUS 

分 类 号：S852.65[农业科学—基础兽医学]