手性膦-酰胺协同金属催化构建多取代吡咯烷的研究进展  

Progress in the Construction of Polysubstituted Pyrrolidine by Chiral Phosphine-amides and Metal Co-catalysis

作　　者：梁国平 陈知刚 罗岚峰 王海飞 Liang Guoping;Chen Zhigang;Luo Lanfeng;Wang Haifei(Hunan University of Technology College of Life Science and Chemistry,Zhuzhou 412007,China)

机构地区：[1]湖南工业大学生命科学与化学学院,湖南株洲412007

出　　处：《广东化工》2023年第7期89-93,共5页Guangdong Chemical Industry

基　　金：湖南省自然科学基金资助项目(2021JJ50005)。

摘　　要：吡咯烷作为一类重要的五元杂环化合物,其骨架广泛存在于许多天然产物、活性药物分子及有机催化剂中,实现此类骨架的构建具有重要的意义。近年来,手性膦-酰胺作为一类重要的多功能配体,通过和金属络合催化甲亚胺叶立德与缺电子烯烃之间的不对称1,3-偶极环加成反应,实现了多取代吡咯烷衍生物的高效、高选择性地构建,本文就这一领域取得的进展做一简单综述。Pyrrolidines,as a class of important five-membered heterocyclic compounds,widely exists in in many natural products,active drug molecules and organic catalysts.It is of great significance to realize the construction of such skeletons.In recent years,chiral phosphine-amides,as a kind of important multifunctional ligands,in coordination with metals,have achieved the efficient and highly selective construction of polysubstituted pyrrolidine derivatives by catalyzing the asymmetric 1,3-dipolar cycloaddition reaction between methylimide ylides and electron-deficient alkenes.This paper briefly reviews the progress made in this field.

关 键 词：手性膦-酰胺 多取代吡咯烷 金属催化 1 3-偶极环加成 

分 类 号：TQ[化学工程]