Insight on metal ions inducing chiral self-assembly of DNA in silica mineralization  

作　　者：Arepati Azhati Lu Han Zhibei Qu Zhouhong Ren Xi Liu Liwei Chen Shunai Che 

机构地区：[1]School of Chemistry and Chemical Engineering,Frontiers Science Center for Transformative Molecules,State Key Laboratory of Metal Matrix Composites,Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs,Shanghai Jiao Tong University,Shanghai 200240,China [2]School of Chemical Science and Engineering,Tongji University,Shanghai 200092,China [3]Department of Medicinal Chemistry,School of Pharmacy,Fudan University,Shanghai 201203,China [4]School of Chemical Science and Engineering,In-situ Center for Physical Sciences,Frontiers Science Center for Transformative Molecules,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《Nano Research》2023年第3期3998-4003,共6页纳米研究（英文版）

基　　金：supported by the National Key Research and Development Program of China(No.2021YFA1200300,S.C.,2021YFA1500300,X.L.);the National Natural Science Foundation of China(No.21931008,S.C.,22072090 X.L,21991153 L.C.);the science foundation of the Shanghai Municipal science and Technology Commission(No.19JC1410300,S.C.).

摘　　要：The self-assembly of DNA provides an attractive approach to understanding structural formation mechanism in living organisms and to assisting applications in materials chemistry.Herein,we investigated the effect of metal ions on chiral self-assembly of DNA through the synthesis of chiral mesostructured silica via self-assembly of metal ions,DNA,and silica source.31 types of multivalent cationic metal ions were found to induce formation of chiral impeller-like DNA-silica complexes due to the chiral stacking of DNA.The strength of the interaction between the metal ion and phosphate group of DNA was speculated for the chiral stacking of DNA due to close distance of adjacent DNA to assure mutual recognition.Theoretical calculations indicated that chiral packing of DNA depends on the stability of the bridging phosphate-metal ion-phosphate bonds of DNA based on electron delocalization in d-orbital conjugation of metal ions.

关 键 词：CHIRALITY DNA DNA-metal ions interaction SILICA ultra-small metal-nanoparticle 

分 类 号：O62[理学—有机化学]