Repurposing organic semiconducting nanomaterials to accelerate clinical translation of NIR-II fluorescence imaging  

作　　者：Xiaoming Hu Fengwei Sun Caijun Zhu Zhen Yang Wei Huang 

机构地区：[1]Strait Laboratory of Flexible Electronics(SLoFE),Strait Institute of Flexible Electronics(SIFE,Future Technologies),Fujian Normal University,Fuzhou 350117,China [2]Jiangxi Key Laboratory of Nanobiomaterials,School of Materials Science and Engineering,East China Jiaotong University,Nanchang 330013,China [3]Frontiers Science Center for Flexible Electronics(FSCFE),MIIT Key Laboratory of Flexible Electronics(KLoFE),Northwestern Polytechnical University,Xi’an 710072,China

出　　处：《Nano Research》2023年第4期5140-5154,共15页纳米研究（英文版）

基　　金：supported by the Natural Science Foundation of Jiangxi Province(Nos.20212BAB214005 and 20212ACB214002);the Research startup fund of East China Jiaotong University(No.465).

摘　　要：Optical imaging possesses important implications for early disease diagnosis,timely disease treatment,and basic medical as well as biological research.Compared with the traditionary near-infrared(NIR-I)window(650-950 nm)optical imaging,the emerging second near-infrared(NIR-II)window optical imaging technology owns the great superiorities of non-invasiveness,nonionizing radiation,and real-time dynamic imaging with the low biological interference,can significantly improve the tissue penetration depth and detection sensitivity,thus expecting to achieve accurate and precise diagnosis of major diseases.Inspired by the conspicuous superiorities,an increasing number of versatile NIR-II fluorophores have been legitimately designed and engineered for precisely deep-tissue mapping-mediated theranostics of life-threatening diseases.Organic semiconducting nanomaterials(OSNs)are derived from organic conjugated molecules withπ-electron delocalized skeletons,which show greatly preponderant prospects in the biomedicine field due to the excellent photoelectric property,tunable energy bands,and fine biocompatibility.In this review,the superiorities of NIR-II fluorescence imaging using OSNs for brilliant visualization various of diseases,including tongue cancer,ovarian cancer,osteosarcoma,bacteria or pathogens infection,kidney dysfunction,rheumatoid arthritis,liver injury,and cerebrovascular function,are emphatically summarized.Finally,the reasonable prospects and persistent efforts for repurposing OSNs to facilitate the clinical translation of NIR-II fluorescence phototheranostics are outlined.

关 键 词：organic semiconducting nanomaterials second near-infrared(NIR-II)fluorescence imaging malignant tumor organic injury infections 

分 类 号：TB383[一般工业技术—材料科学与工程]