Selenium-engineered bottom-up-synthesized lanthanide coordination nanoframeworks as efficiency X-ray-responsive radiosensitizers  

作　　者：Liwen Zhu Leung Chan Junping Wang Mingkai Chen Fei Cai Yuan Tian Li Ma Tianfeng Chen 

机构地区：[1]Department of Chemistry,and Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications,Jinan University,Guangzhou 510632,China

出　　处：《Nano Research》2023年第4期5169-5175,共7页纳米研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.21877049,22177038,and 32171296);Guangdong Natural Science Foundation(Nos.2022A1515012235 and 2020B1515120043);Guangdong Pearl River Talent Program(No.2017GC010354);Innovation Team Project in Guangdong Colleges and Universities(Nos.2019KCXTD008 and 2019KTSCX012).

摘　　要：Radiotherapy is one of the main therapeutic methods for cancers;however,nonselective killing of normal cells and tumor cells by X-ray inevitably results in toxicity and side effects.Developing low-toxicity and high-efficiency radiosensitizers to reduce the practical dose of X-ray is a promising approach to overcoming these side effects.Here,we report the use of carboxylatecontaining organic ligands to construct one-dimensional high-Z lanthanide chains for efficient response to X-ray.The onedimensional lanthanide chains are stacked through weak interactions to form coordination nanoframeworks in the presence of polyethylenimine(PEI).The morphology and activity of the synthesized nanoframeworks can be regulated through selenium atom engineering.This study presents a promising approach for effective radiotherapy through selenium-engineering stable lanthanide nanoframeworks with precise coordination structures as radiosensitizers to mitigate X-ray side effects.

关 键 词：SELENIUM lanthanide coordination nanoframeworks radiotherapy RADIOSENSITIZERS 

分 类 号：O62[理学—有机化学]