Ultra-bright near-infrared-IIb emitting Zn-doped Ag_(2)Te quantum dots for noninvasive monitoring of traumatic brain injury  

作　　者：Yifei Zhou Biao Huang Shi-Hui Chen Shu-Lin Liu Mingxi Zhang Ran Cui 

机构地区：[1]College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072,China [2]State Key Laboratory of Advanced Technology for Materials Synthesis and Processing,Wuhan University of Technology,Wuhan 430070,China [3]State Key Laboratory of Medicinal Chemical Biology,Tianjin Key Laboratory of Biosensing and Molecular Recognition,Research Centre for Analytical Sciences,College of Chemistry,Nankai University,Tianjin 300071,China

出　　处：《Nano Research》2023年第2期2719-2727,共9页纳米研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.22174105 and 21974104);the National Key Research and Development(R&D)Program of China(No.2020YFA0908800);Large-scale Instrument and Equipment Sharing Foundation of Wuhan University.

摘　　要：The long-wavelength region of the near-infrared-IIb(NIR-IIb,1,500–1,700 nm)imaging window has become an ideal window for in vivo imaging due to the suppressed photon scattering and near-zero autofluorescence of biological tissues.Therefore,it is necessary to develop fluorescent probes with excellent fluorescence performance and stability for NIR-IIb fluorescence imaging.In this work,zinc-doped silver telluride quantum dots(Zn:Ag_(2)Te QDs)with bright fluorescence in the NIR-IIb window were synthesized.The introduction of Zn dopants inhibited crystal defects and reduced non-radiative transitions.Therefore,the quantum yield and fluorescence lifetime of Zn:Ag_(2)Te QDs were significantly improved.In addition,Zn-doping increased the number of ligands on the surface of QDs,thus enhancing the colloidal stability of Zn:Ag_(2)Te QDs.Moreover,the PEGylated Zn:Ag_(2)Te QDs with high absolute quantum yield realized noninvasive imaging of cerebral vascular of mouse with high resolution able to distinguish blood capillary,which could be utilized to monitor the brain condition of mice after traumatic brain injury.

关 键 词：near-infrared-IIb(NIR-IIb)window silver telluride quantum dots fluorescence in vivo imaging 

分 类 号：O61[理学—无机化学]