Natural biopolymers derived hydrogels with injectable,self-healing,and tissue adhesive abilities for wound healing  

作　　者：Bin Kong Rui Liu Yi Cheng Xiaodong Cai Junying Liu Dagan Zhang Hui Tan Yuanjin Zhao 

机构地区：[1]Department of Rheumatology and Immunology,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210002,China [2]Respiratory department,Shenzhen Children's Hospital,Shenzhen 518038,China [3]Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325001,China

出　　处：《Nano Research》2023年第2期2798-2807,共10页纳米研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.82101184 and 82102511);the Shenzhen Fundamental Research Program(Nos.JCYJ20210324102809024,JCYJ20190813152616459 and JCYJ20210324133214038);the Shenzhen PhD Start-up Program(Nos.RCBS20210609103713045,ZDSYS20200811142600003,JCYJ20180228162928828,and JCYJ20190806161409092);the Natural Science Foundation of Guangdong Province(No.2020A1515110780);the Guangdong Basic and Applied Basic Research Foundation(No.2021B1515120054);the Natural Science Foundation of Jiangsu(No.BK20210021);the Research Project of Jiangsu Province Health Committee(No.M2021031).

摘　　要：Developing a biocompatible and multifunctional adhesive hydrogel with injectability and self-healing ability for promoting wound healing is highly anticipated in various clinical applications.In this paper,we present a novel natural biopolymer-derived hydrogel based on the aldehyde-modified oxidized guar gum(OGG)and the carboxymethyl chitosan(CMCS)for efficiently improving wound healing with the encapsulation of vascular endothelial growth factor(VEGF).As the hydrogels are synthesized via the dynamically reversible Schiff base linkages,it is imparted with excellent self-healing ability and good shear thinning behavior,which make the hydrogel be easily and conveniently injected through a needle.Besides,the physiochemical properties,including porous structure,mechanical strength and swelling ratio of the hydrogel can be well controlled by regulating the concentrations of the OGG.Moreover,the hydrogel can attain strong adhesion to the tissues at physiological temperature based on the Schiff base between the aldehyde group on the hydrogel and the amino group on the tissue.Based on these features,we have demonstrated that the VEGF encapsulated hydrogel can adhere tightly to the defect tissue and improve wound repair in the rat model of defected skin by promoting cell proliferation,angiogenesis,and collagen secretion.These results indicate that the multifunctional hydrogel is with great scientific significance and broad clinical application prospects.

关 键 词：hydrogel SELF-HEALING INJECTABILITY tissue adhesive wound healing 

分 类 号：O63[理学—高分子化学]