Relay-type sensing mode:A strategy to push the limit on nanomechanical sensor sensitivity based on the magneto lever  

作　　者：Depeng Rao Tianhao Yan Zihan Qiao Yu Wang Yongpei Peng Han Tu Shangquan Wu Qingchuan Zhang 

机构地区：[1]CAS Key Laboratory of Mechanical Behavior and Design of Material,Department of Modern Mechanics,University of Science and Technology of China,Hefei 230027,China

出　　处：《Nano Research》2023年第2期3231-3239,共9页纳米研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.11627803,12072339,and 32061160475);USTC Research Funds of the Double First-Class Initiative(No.YD2480002003).

摘　　要：Ultrasensitive molecular detection and quantization are crucial for many applications including clinical diagnostics,functional proteomics,and drug discovery;however,conventional biochemical sensors cannot satisfy the stringent requirements,and this has resulted in a long-standing dilemma regarding sensitivity improvement.To this end,we have developed an ultrasensitive relay-type nanomechanical sensor based on a magneto lever.By establishing the link between very weak molecular interaction and five orders of magnitude larger magnetic force,analytes at ultratrace level can produce a clearly observable mechanical response.Initially,proof-of-concept studies showed an improved detection limit up to five orders of magnitude when employing the magneto lever,as compared with direct detection using probe alone.In this study,we subsequently demonstrated that the relay-type sensing mode was universal in application ranging from micromolecule to macromolecule detection,which can be easily extended to detect enzymes,DNA,proteins,cells,viruses,bacteria,chemicals,etc.Importantly,we found that,sensitivity was no longer subject to probe affinity when the magneto lever was sufficiently high,theoretically,even reaching single-molecule resolution.

关 键 词：relay-type sensing mode magneto lever nanomechanical sensor ULTRASENSITIVITY 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]