A non-surgical suturing strategy for rapid cardiac hemostasis  

作　　者：Yuan Gao Jun Zhang Nan Cheng Zhong Liu Yuan-Bin Wu Qian-Qian Zhou Chen-Yan Li Miao Yu Seeram Ramakrishna Rong Wang Yun-Ze Long 

机构地区：[1]Collaborative Innovation Center for Nanomaterials&Devices,College of Physics,Qingdao University,Qingdao 266071,China [2]Department of Adult Cardiac Surgery,the Sixth Medical Center of PLA General Hospital,Beijing 100084,China [3]Institute of Health Service and Transfusion Medicine,Beijing 100850,China [4]Center for Nanofibers&Nanotechnology,Department of Mechanical Engineering,National University of Singapore,Singapore 117574,Singapore [5]State Key Laboratory of Bio-Fibers&Eco-Textiles,Qingdao 266071,China

出　　处：《Nano Research》2023年第1期810-821,共12页纳米研究（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.51973100 and 11904193);the National Key Research and Development Project of China(No.2019YFC0121402);the State Key Laboratory of Bio-Fibers and Eco-Textiles,Qingdao University(Nos.RZ2000003334,ZDKT202108,and G2RC202022);Shandong Province Introduction of Top Talents(Team)One Thing,One Discussion(DC1900013728).

摘　　要：As the central organ of the human body,once the heart is damaged,it will cause devastating damage to the circulation system of the whole body,often leading to rapid death.Currently,the only treatment option to stop bleeding in penetrating cardiac injuries is surgical suturing,which is extremely complex and risky.In addition,it is difficult to implement this kind of treatment in battlefields with poor medical conditions.Therefore,there is an urgent need to develop an effective cardiac hemostasis strategy.In this work,we propose a two-step hemostasis strategy that can effectively stop bleeding for penetrating heart injuries.That is,cardiac hemostatic plug(CHP)is made from the nanocomposite(polylactic acid/gelatin/absorbable hemostatic particles,PLA/GEL/AHP)with high biosafety,excellent hemostatic performance,and degradability which is used to block cardiac bleeding,and then wound surface is sealed by in-situ electrospun medical glue fibers(N-octyl-2-cyanoacrylate,interfacial toughness:221±23 J·m−2),thus completing cardiac hemostasis(porcine heart with 1 cm diameter penetrating wound).The hemostasis process is simple and quick(<2 min).In addition,it is worth mentioning that we have also proposed a new composite method based on solution blow spinning that is suitable for doping various functional particles,and the PLA/GEL/AHP composite nanofiber membrane prepared by this method is also a promising hemostatic material.

关 键 词：heart cardiac hemostasis nanocomposite solution blow spinning electrospinning 

分 类 号：R541[医药卫生—心血管疾病]