Modulating planarity of cyanine dye to construct highly stable Haggregates for enhanced photothermal therapy  

作　　者：Kai Wei Yanxin Wu Pengyu Li Xian Zheng Chendong Ji Meizhen Yin 

机构地区：[1]State Key Laboratory of Chemical Resource Engineering,Beijing Laboratory of Biomedical Materials,Beijing University of Chemical Technology,Beijing 100029,China

出　　处：《Nano Research》2023年第1期970-979,共10页纳米研究（英文版）

基　　金：This work was financially supported by the National Natural Science Foundation of China(Nos.52130309 and 51903014);Beijing Natural Science Foundation(No.2202043);Changzhou Sci&Tech Program(No.CJ20210041).

摘　　要：Self-assembly of dyes has become a flexible strategy to modulate their photophysical properties.H-aggregates show great potential to increase heat generation,while the precise designing of H-aggregates as efficient photothermal agents is still challenging.Herein,a quinoline cyanine(QCy)is developed for constructing stable H-aggregated nanoparticles(NPs)to significantly enhance photostability and photothermal conversion efficiency(PCE).With symmetrical rigid planar quinoline structures,QCy has a small and symmetrical dihedral angle(11.9°),which ensures excellent molecular planarity.In aqueous solution,the planar QCy can form closeπ–πmolecular stacking,and fast self-assemble into stable H-aggregates even at low concentrations(1×10−7 M).QCy H-aggregates are sphere-like NPs(QCy NPs)with an average diameter of 120 nm and exhibit high stability.H-aggregation of QCy significantly enhances PCE from 20.1%(non-H-aggregated QCy)to 63.8%(QCy NPs).In addition,the positive charge of quaternarized quinoline provides mitochondrial anchoring ability,which further enhances the photothermal effect.With high PCE and tumor accumulation,QCy NPs in low-doses have been successfully used in photoacoustic imaging-guided tumor photothermal therapy.

关 键 词：H-aggregation-enhanced photothermal effect molecular planarity quinoline cyanine mitochondrial anchoring LOW-DOSE 

分 类 号：O62[理学—有机化学]