美洛昔康血浆样品分析方法验证及药动学研究  

Validation and Pharmacokinetic Study on Plasma Samples with Meloxicam

作　　者：盛利娟 王永庆 李成蹊 王宏民 林霞 杨子毅 SHENG Li-juan;WANG Yong-qing;LI Cheng-xi;WANG Hong-ming;LIN Xia;YANG Zi-yi(School of Sciences and Health Engineering,Jiangnan University,Jiangsu Wuxi 214000,China)

机构地区：[1]江南大学生命科学与健康工程学院,江苏无锡214000

出　　处：《广州化工》2023年第4期126-128,共3页GuangZhou Chemical Industry

摘　　要：建立美洛昔康在大鼠体内样品的分析方法并验证,以用于美洛昔康制剂的体内药代动力学研究。以吡咯昔康为内标,液液-萃取法处理体内血浆样品,通过高效液相色谱法(HPLC)进行含量测定。结果显示,该方法专属性好,最低定量下线可达0.5μg/mL,线性范围为0.5~100μg/mL,精密度、准确度及提取回收率均符合质量标准,可用于美洛昔康制剂的药动学研究,为临床镇痛制剂的开发提供参考。A method for the analysis of meloxicam in rats and verify it for the study of pharmacokinetics of meloxicam preparation was established.Using pyrroxicam as internal standard,plasma samples were treated with liquid-liquid-extraction method and determined by high performance liquid chromatography(HPLC).The results showed that the method had good specificity,the minimum quantification line was 0.5μg/mL,the linear range was 0.5~100μg/mL,the precision,accuracy and extraction recovery were in line with the quality standards.The method could be used for pharmacokinetic study of meloxicam preparation,and provide reference for the development of clinical analgesic agents.

关 键 词：美洛昔康 高效液相色谱法 药代动力学 

分 类 号：R944.1[医药卫生—药剂学]