比索洛尔联合贝那普利对不同基础心率高血压并心力衰竭患者左室结构及血压调控的影响研究  

Effect of bisoprolol combined with benazepril on left ventricular structure and blood pressure regulation in patients with hypertension and heart failure at different basal heart rates

作　　者：张永佳 罗丽琼 黄伟佳 陈德俊[1] 黄鸿辉 吴思仪 ZHANG Yong-jia;LUO Li-qiong;HUANG Wei-jia(Department of Cardiovascular Medicine,Puning Overseas Chinese Hospital,Jieyang 515300,China)

机构地区：[1]广东省揭阳市普宁华侨医院心血管内科,515300

出　　处：《中国实用医药》2023年第8期8-12,共5页China Practical Medicine

摘　　要：目的探析比索洛尔联合贝那普利对不同基础心率高血压并心力衰竭患者左室结构及血压调控的影响。方法240例高血压并心力衰竭患者,按心率不同分为A组(心率70~79次/min)、B组(心率80~89次/min)、C组(心率≥90次/min),各80例。三组患者均接受比索洛尔联合贝那普利治疗。比较两组的血压调控情况[收缩压(SBP)、舒张压(DBP)]、心率、左心室射血分数(LVEF)、左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、不良反应发生情况。结果三组治疗前、治疗6周后的SBP、DBP比较,差异无统计学意义(P>0.05)。三组治疗6周后的SBP、DBP均低于治疗前,差异有统计学意义(P<0.05)。A组治疗前的心率低于B组、C组,LVEF高于B组、C组,差异具有统计学意义(P<0.05);B组治疗前的心率低于C组,LVEF高于C组,差异具有统计学意义(P<0.05);三组治疗6周后的心率均低于治疗前、LVEF均高于治疗前,差异有统计学意义(P<0.05)。三组治疗6周后的心率、LVEF比较,差异无统计学意义(P>0.05)。A组治疗前的LVESD、LVEDD小于B组、C组,差异具有统计学意义(P<0.05);B组治疗前的LVESD、LVEDD小于C组,差异具有统计学意义(P<0.05);三组治疗6周后的LVESD、LVEDD均小于治疗前,差异有统计学意义(P<0.05)。三组治疗6周后的LVESD、LVEDD比较,差异无统计学意义(P>0.05)。A组、B组、C组不良反应发生率分别为22.50%、63.75%、83.75%。A组不良反应发生率低于B组、C组,且B组低于C组,差异有统计学意义(P<0.05)。结论比索洛尔与贝那普利联合治疗方案在不同基础心率高血压并心力衰竭中的用药效果显著,均可达到降低血压、心率,改善心功能的治疗效果。但基础心率较高者的不良反应发生风险相对较高,因而需重视其用药时间、剂量的调整。Objective To investigate the effect of bisoprolol combined with benazepril on left ventricular structure and blood pressure regulation in patients with hypertension and heart failure at different basal heart rates.Methods A total of 240 patients with hypertension and heart failure were divided into group A(heart rate 70-79 beats/min),group B(heart rate 80-89 beats/min)and group C(heart rate≥90 beats/min),with 80 cases in each group.All three groups were treated by bisoprolol and benazepril.Both groups were compared in terms of blood pressure regulation[systolic blood pressure(SBP),diastolic blood pressure(DBP)],heart rate,left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),left ventricular enddiastolic diameter(LVEDD),and the occurrence of adverse reactions.Results Before treatment and 6 weeks after treatment,there was no statistically significant difference in SBP and DBP among the three groups(P>0.05).The SBP and DBP of the three groups after 6 weeks of treatment were lower than those before treatment,and the difference was statistically significant(P<0.05).Before treatment,the heart rate of group A was lower than that of group B and group C,and the LVEF was higher than that of group B and group C.The differences were statistically significant(P<0.05).Before treatment,the heart rate of group B was lower than that of group C,and the LVEF was higher than that of group C.The differences were statistically significant(P<0.05).After 6 weeks of treatment,the heart rate of the three groups was lower than that before treatment,and the LVEF was higher than that before treatment.The differences were statistically significant(P<0.05).There was no statistically significant difference in heart rate and LVEF among the three groups after 6 weeks of treatment(P>0.05).Before treatment,the LVESD and LVEDD of group A were lower than those of group B and group C,and the difference was statistically significant(P<0.05).Before treatment,theLVESD and LVEDD of group B were lower than those of group

关 键 词：比索洛尔 贝那普利 基础心率 高血压 心力衰竭 左室结构 血压调控 

分 类 号：R541.6[医药卫生—心血管疾病] R544.1[医药卫生—内科学]