O型血孕妇血清免疫球蛋白G抗体效价与新生儿溶血病发病率的关系  

Relationship between serum immunoglobulin G antibody titer of pregnant women with type O blood and incidence of hemolytic disease of newborn

作　　者：李艳 LI Yan(Xinfeng County Maternal and Child Health Hospital,Ganzhou 341600 Jiangxi,China)

机构地区：[1]信丰县妇幼保健院,江西赣州341600

出　　处：《中国民康医学》2023年第7期123-125,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析O型血孕妇血清IgG抗体效价与新生儿溶血病(HDN)发病率的关系。方法:回顾性分析2020年4月至2022年3月于该院产检并分娩的90名O型血孕妇的临床资料,观察孕妇IgG抗体效价的分布和不同IgG抗体效价孕妇所产新生儿的HDN发病率,采用Spearman相关性分析孕妇IgG抗体效价与HDN发病率的关系,以溶血3项检查结果作为金标准,观察孕妇IgG抗体效价在HDN诊断中的效能以及与金标准的一致性。结果:90名孕妇中IgG抗体效价≥1∶64共39名,占43.33%(39/90)。Spearman相关性分析结果显示,孕妇IgG抗体效价与HDN发病率呈正相关(r>0,P<0.05)。以1∶64作为临界值,孕妇IgG抗体效价诊断HDN的灵敏度为85.71%(12/14),特异度为100.00%(76/76),准确度为97.78%(88/90);Kappa检验结果显示,孕妇IgG抗体效价诊断HDN与金标准的一致性为几乎完全一致(Kappa值=0.910,P<0.05)。结论:O型血孕妇IgG抗体效价与HDN发病率呈正相关,孕妇IgG抗体效价诊断HDN的灵敏度为85.71%,特异度为100.00%,准确度为97.78%,其结果与金标准的一致性为几乎完全一致。Objective:To analyze relationship between serum immunoglobulin G antibody titer of pregnant women with type O blood and incidence of hemolytic disease of newborn(HDN).Methods:The clinical data of 90 pregnant women with type O blood who were examined and delivered in this hospital from April 2020 to March 2022 were retrospectively analyzed.The distribution of IgG antibody titers in the pregnant women and the incidence of HDN in the newborns delivered by the pregnant women with different IgG antibody titers were observed.Spearman correlation analysis was used to analyze the relationship between the IgG antibody titer in these pregnant women and the incidence of HDN.Using the results of three hemolysis tests as the gold standard,the efficacy of IgG antibody titer in the diagnosis of HDN and its consistency with the gold standard were observed.Results:Among the 90 pregnant women,39 had IgG antibody titer≥1∶64,accounting for 43.33%(39/90).Spearman correlation analysis showed that the incidence of HDN was positively correlated with the IgG antibody titer in these pregnant women(r>0,P<0.05).Using 1∶64 as the cutoff value,the sensitivity,the specificity and the accuracy of the IgG antibody titer in the diagnosis of HDN were 85.71%(12/14),100.00%(76/76)and 97.78%(88/90),separately.Kappa test showed that the consistency of the IgG antibody titer in the diagnosis of HDN in the pregnant women was almost completely consistent with the gold standard(Kappa value=0.910,P<0.05).Conclusions:The IgG antibody titer in the pregnant women with type O blood is positively correlated with the incidence of HDN.The sensitivity,the specificity and the accuracy of the IgG antibody titer of the pregnant women in the diagnosis of HDN were 85.71%,100.00%and 97.78%,separately;and they are almost completely consistent with the gold standard.

关 键 词：新生儿溶血病 发病率 O型血孕妇 IGG抗体 相关性 诊断 效能 

分 类 号：R722.18[医药卫生—儿科]