人工生物瓣膜退化衰败的机制及预防  

Mechanism and prevention of structural valve degeneration and Bioprosthetic valve failure

作　　者：储庆 高华炜 Chu Qing;Gao Huawei(Department of Cardiac Surgery,Fuwai Hospital,Chinese Academy of Medical Sciences,Beijing 100037,China)

机构地区：[1]中国医学科学院阜外医院心外科,北京100037

出　　处：《中华胸心血管外科杂志》2023年第3期180-185,共6页Chinese Journal of Thoracic and Cardiovascular Surgery

摘　　要：人工生物瓣膜的结构性退化和衰败是限制生物瓣膜使用寿命的重要原因。探讨生物瓣膜结构性退化和衰败的分子机制和病理过程是改善瓣膜耐久性和提高生物瓣膜置换患者预后的重要方式。本文系统总结了生物瓣膜结构性退化和衰败的定义、发病机制、相关分子通路以及预防策略,希望为生物瓣膜退化和衰败机制研究和临床干预靶点的开发提供理论依据。Structural valve degeneration(SVD)and bioprosthetic valve failure(BVF)seriously limits the service life of biological valves.Exploring the molecular mechanism and pathological process of SVD and BVF is an important way to improve valve durability and prognosis of patients with biological valves replacement.In this review,we systematically summarized the definition,pathogenesis,related molecular pathways and prevention strategies of SVD and BVF.This review is expected to provide a theoretical basis for the study of the mechanism of SVD and BVF and the development of clinical intervention targets.

关 键 词：生物瓣膜 瓣膜置换 分子通路 病理过程 预防策略 发病机制 干预靶点 分子机制 

分 类 号：R654.2[医药卫生—外科学] R318.11[医药卫生—临床医学]