运动奖赏效应及其神经生物学机制的研究进展  

Progress in research on the exercise reward and the neurobiological mechanisms of exercise reward

作　　者：牟连伟 葛未未 王海英[4] 邱平学 MU Lian-Wei;GE Wei-Wei;WANG Hai-Ying;QIU Ping-Xue(Guangzhou Sport University,Guangzhou 510500,China;Beijing Sport University,Beijing 100084,China;Hefei No.4 High School,Hefei 230061,China;Hebei Sport University,Shijiazhuang 050041,China)

机构地区：[1]广州体育学院,广州510500 [2]北京体育大学,北京100084 [3]合肥市第四中学,合肥230061 [4]河北体育学院,石家庄050041

出　　处：《生命科学》2023年第3期360-366,共7页Chinese Bulletin of Life Sciences

基　　金：广州体育学院青年博士资助项目(7230180235)。

摘　　要：身体活动不足已经成为当今社会的公共卫生问题。深入理解运动的奖赏效应及其可能的神经生物学机制,将为改善身体活动不足提供科学有效的干预靶点。本文指出运动是一种典型的自然奖赏行为。大脑奖赏相关的腹侧背盖区-伏隔核的多巴胺能神经环路、前额叶皮质-伏隔核的谷氨酸能神经投射、红核-腹侧背盖区的谷氨酸能神经投射是调控运动奖赏效应的关键神经环路机制。此外,多巴胺、内源性大麻素系统和内源性阿片肽等多种神经分子参与了运动奖赏效应的调控。然而,大脑奖赏系统的过度激活将会导致运动成瘾。Physical inactivity is recently recognized as a public health problem.Understanding the exercise reward and its neurobiological mechanisms will provide intervention targets for improving physical inactivity.Physical exercise is rewarding.Multiple neural circuits such as the ventral tegmental area-nucleus accumbens,the prefrontal cortex-nucleus accumbens,and the red nucleus ventral tegmental area are involved in the regulation of exercise reward.In addition,dopamine,endocannabinoid system,and endogenous opioid peptides are involved in the regulation of exercise reward.However,over-activation of the brain’s reward system can lead to exercise addiction.

关 键 词：运动奖赏 前额叶皮质 腹侧背盖区 伏隔核 红核 运动成瘾 

分 类 号：G804.2[文化科学—运动人体科学] Q426[文化科学—体育学]