糖尿病肾病主要发病机制的研究进展  

Research progress on main pathogenesis of diabetic nephropathy

作　　者：李佳佳 黄皓 陶立坚[1,2] 谢艳云[1,2] LI Jia-Jia;HUANG Hao;TAO Li-Jian;XIE Yan-Yun(Department of Nephrology,Xiangya Hospital,Central South University,Changsha 410008,China;Hunan Provincial Key Laboratory of Organ Fibrosis,Changsha 410008,China;Department of Cell Biology,College of Life Sciences,Central South University,Changsha 410013,China)

机构地区：[1]中南大学湘雅医院肾脏内科,长沙410008 [2]器官纤维化湖南省重点实验室,长沙410008 [3]中南大学生命科学学院细胞生物学系,长沙410013

出　　处：《生命科学》2023年第3期396-404,共9页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(82073918,82173877);湖南省重点研发计划项目(2021SK2015);湖南省自然科学基金项目(2021JJ41039)。

摘　　要：糖尿病肾病是糖尿病微血管并发症之一,同时也是引起终末期肾脏病的重要病因。临床上主要以持续存在的白蛋白尿和(或)肾小球滤过率进行性下降为特征。糖尿病肾病致病机制复杂,目前普遍认为氧化应激、炎症和自噬是其主要的发病机制。临床上还没有针对糖尿病肾病治疗的药物,糖尿病肾病的治疗依然是亟待攻克的一个重点和难点。现对影响糖尿病肾病进展的三大主要发病机制进行一个总结性概括,以期为糖尿病肾病药物的研发带来一些新的思路和启发。Diabetic nephropathy is one of the microvascular complications of diabetes mellitus and an important cause of end-stage renal disease.It is characterized clinically by persistent albuminuria and/or a progressive decrease in glomerular filtration rate.The pathogenesis of diabetic nephropathy is complex,and oxidative stress,inflammation,and autophagy are generally considered to be its main pathogenic mechanisms.The treatment of diabetic nephropathy is still a key and difficult task to be tackled as there are no efficient drugs for the treatment of diabetic nephropathy.This article provides a summary of the three major pathogenic mechanisms affecting the progression of diabetic nephropathy,with the aim of bringing some new ideas and inspiration to the development of efficient drugs for the treatment of diabetic nephropathy.

关 键 词：糖尿病肾病 机制 氧化应激 炎症 自噬 

分 类 号：R587.1[医药卫生—内分泌] R692[医药卫生—内科学]