Monkeypox and the perinatal period:what does maternal-fetal medicine need to know?  

作　　者：Kai Yan Lu-Kun Tang Fei-Fan Xiao Peng Zhang Chun-Mei Lu Li-Yuan Hu Lai-Shuan Wang Guo-Qiang Cheng Wen-Hao Zhou 

机构地区：[1]Department of Neonatology,Children Hospital of Fudan University,National Children's Medical Center,Shanghai 201102,China [2]Kunming Medical University,Kunming 678400,China [3]Department of Neonatology,Dehong People's Hospital,Kunming 650000,China [4]Department of Nursing,Children's Hospital of Fudan University,National Children's Medical Center,Shanghai 201102,China [5]Key Laboratory of Neonatal Diseases of National Health Ministry,Shanghai 201102,China

出　　处：《World Journal of Pediatrics》2023年第3期213-223,共11页世界儿科杂志（英文版）

摘　　要：Background After the global elimination of smallpox,monkeypox has become the most threatening orthopoxvirus to human health.Very few studies have been reported on pregnant women and newborns.In the case of monkeypox infection,the virus can cause serious adverse pregnancy events in women,which can lead to fetal or neonatal death.Data sources We made a comprehensive review after an extensive literature search in the PubMed/Medline database and websites concerning smallpox and monkeypox.Results Two case reports reported a total of nine pregnant women,six of whom had fetal deaths.In the autopsy of a stillbirth,researchers found that the placenta was infected with monkeypox virus,but the mechanism of infection remains unclear.Smallpox vaccine should be administered to acutely exposed pregnant women and newborns.Several novel recombinant vac-cinia immunogloblin(rVIG)and human-specific monoclonal antibodies are being developed for the prevention and treatment of monkeypox virus infection.After the fetus was delivered,the newborn should take a bath as soon as possible to remove the amniotic fluid and dirt from the body.The appropriate isolation protocol for the newborn should be selected according to the infection status of the mother.It is not known whether monkeypox virus is present in breast milk,and pasteurized breast milk can be given to newborns when breastfeeding is considered.Conclusion This review presents an overview of monkeypox in the perinatal period and guides the future research direction.

关 键 词：FETAL MATERNAL MONKEYPOX NEWBORN 

分 类 号：R511[医药卫生—内科学]