基于MRI直方图组学模型对特殊部位异位妊娠的诊断价值  

Diagnostic value of ectopic pregnancy in special site based on MRI histogram group model

作　　者：丁慧 姚苗苗 杨冬 李响 蔡小威 DING Hui;YAO Miaomiao;YANG Dong;LI Xiang;CAI Xiaowei(Department of Gynecology,First People’s Hospital of Suqian,Suqian,Jiangsu 223800,China;Department of Medical Imaging,First People’s Hospital of Suqian,Suqian,Jiangsu 223800,China;Department of Nuclear Medicine,First People’s Hospital of Suqian,Suqian,Jiangsu 223800,China)

机构地区：[1]江苏省宿迁市第一人民医院妇科,江苏宿迁223800 [2]江苏省宿迁市第一人民医院医学影像科,江苏宿迁223800 [3]江苏省宿迁市第一人民医院核医学科,江苏宿迁223800

出　　处：《中国优生与遗传杂志》2023年第4期751-756,共6页Chinese Journal of Birth Health & Heredity

摘　　要：目的 探讨磁共振成像(MRI)直方图组学模型对特殊部位异位妊娠的诊断价值。方法 研究对象为江苏省宿迁市第一人民医院2018年8月至2022年7月经手术病理证实的120例异位妊娠患者,依据异位妊娠的发生部位分为特殊部位组(n=35)和非特殊部位组(n=85)。收集记录两组患者的一般资料及MRI图像并进行勾画,计算出全容积ADC值、对比度、能量、相关性、ADC熵值作为直方图组学参数。单因素分析两组患者的直方图参数,建立Lasso模型并筛选直方图参数。通过受试者工作特征曲线(ROC)的线下面积(AUC)评估直方图组学诊断效能的精准度。结果 特殊部位组(n=35)和非特殊部位组(n=85)在年龄、体质指数、吸烟史、饮酒史、高血压、高脂血症、糖尿病、盆腔炎性疾病、下腹部手术史、异位妊娠史、顺产次数、剖宫产次数、流产史的差异均无统计学意义(P>0.05),资料具有可比性。两组患者在40thADC、50thADC、60thADC、70thADC、80thADC、90thADC、ADCmax、ADCmin、ADCmean、能量、相关性、熵的差异均有统计学意义(P<0.05)。经Lasso筛选,进入模型的变量有50thADC、ADCmax、ADCmin、相关性、熵。50thADC、ADCmax、ADCmin、相关性、熵的AUC分别为0.718、0.802、0.816、0.827、0.706,均有诊断价值。相关性的ROC曲线下面积最大,AUC=0.827(95%CI:0.762~0.965),C-index为0.876(95%CI:0.781~0.997),灵敏度为91.02%,特异度为61.93%,诊断价值最高。结论 MRI直方图组学模型对特殊部位异位妊娠的诊断价值较高,参数间相比,相关性的诊断价值最高。Objective To explore the value of magnetic resonance imaging(MRI)histogram model in the diagnosis of ectopic pregnancy in special sites.Methods The subjects were 120 patients with ectopic pregnancy confirmed by operation and pathology from August 2018 to July 2022 in the First People’s Hospital of Suqian,Jiangsu province.According to the location of ectopic pregnancy,they were divided into two groups:special site group(n=35)and non-special site group(n=85).The general data and MRI images of the two groups were collected and delineated,and the full volume ADC value,contrast,energy,correlation and ADC entropy were calculated as histogram parameters.The histogram parameters of the two groups were analyzed by univariate analysis,and the LASSO model was established and the histogram parameters were screened.The accuracy of histogram diagnosis was evaluated by the offline area(AUC)of the subject working characteristic curve(ROC).Results There was no significant difference in age,body mass index,smoking history,drinking history,hypertension,hyperlipidemia,diabetes,pelvic inflammatory disease,lower abdominal operation history,ectopic pregnancy history,spontaneous delivery times,cesarean section times and abortion history between the special site group and the non-special site group(P>0.05).The data are comparable.There were significant differences in 40th ADC,50th ADC,60th ADC,70th ADC,80th ADC,90th ADC,ADCmax,ADCmin,ADCmean,energy,correlation and entropy between the two groups(P<0.05).After Lasso screening,the variables entering the model are 50th ADC,ADCmax,ADCmin,correlation and entropy.The AUC of 50th ADC,ADCmax,ADCmin,correlation and entropy were 0.718,0.802,0.816,0.827 and 0.706 respectively,which were of diagnostic value.The area under the ROC curve of correlation is the largest,AUC=0.827(95%CI:0.762‒0.965),C-index is 0.876(95%CI:0.781‒0.997),sensitivity is 91.02%,specificity is 61.93%,and diagnostic value is the highest.Conclusion MRI enhanced sequence histogram model is of high value in the diagnosis of ec

关 键 词：磁共振 特殊部位异位妊娠 直方图 诊断价值 

分 类 号：R714.22[医药卫生—妇产科学] R445.2[医药卫生—临床医学]