Host cell cycle checkpoint as antiviral target for SARS-CoV-2 revealed by integrative transcriptome and proteome analyses  

作　　者：Liyan Sui Letian Li Yinghua Zhao Yicheng Zhao Pengfei Hao Xuerui Guo Wenfang Wang Guoqing Wang Chang Li Quan Liu 

机构地区：[1]Department of Infectious Diseases,Infectious diseases and Pathogen Biology Center,Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education,The First Hospital of Jilin University,State Key Laboratory of Zoonotic Diseases,Changchun,130021,China [2]Research Unit of Key Technologies for Prevention and Control of Virus Zoonoses,Chinese Academy of Medical Sciences,Changchun Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Changchun,130117,China [3]College of Basic Medical Science,Jilin University,Changchun,130021,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第2期341-343,共3页信号转导与靶向治疗（英文）

基　　金：This work was supported by grant from the National Natural Science Foundation of China(81972873,82002165,81871699,and 82072330);the Biosafety Research Special Plan of the Logistics Support Department of the Military Commission(923070201202);the young and middle-aged science and technology innovation leaders and teams of the Jilin Provincial Department of Science and Technology(20200301001RQ);China Ministry of Science and Technology Key Research and Development Program(2022YFF1203204);Jilin Province Pathogen and Infection Informatics International Joint Research Center(20210504004GH);the Pearl River Talent Plan in Guangdong Province of China(2019CX01N111);the Scientific and Technological Research Projects of Guangzhou,China(202103000008);the Medical Innovation Team Project of Jilin University(2022JBGS02).

摘　　要：Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of the COVID-19 pandemic,has posed severe threats to global public health,highlighting an urgent need to understand its pathogenesis and to develop antiviral therapies.Both DNA and RNA viruses can modulate cell cycle progression to maximize their replication.1 However,the effects of SARS-CoV-2 on cell cycle progression remains largely unknown.

关 键 词：acute RESPIRATORY cycle 

分 类 号：R563.1[医药卫生—呼吸系统]