DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice  

作　　者：Shushu Zhou Shimin Yuan Jintao Zhang Lanlan Meng Xin Zhang Siyu Liu Guangxiu Lu Ge Lin Mingxi Liu Yue-Qiu Tan 

机构地区：[1]State Key Laboratory of Reproductive Medicine,Department of Histology and Embryology,School of Basic Medical Sciences,Nanjing Medical University,Nanjing,211166,China [2]Reproductive Medicine Center,Department of Obstetrics and Gynecology,the First Affiliated Hospital of Anhui Medical University,Hefei,230022,China [3]Clinical Research Center for Reproduction and Genetics in Hunan Province,Reproductive and Genetic Hospital of CITIC-XIANGYA,Changsha,410008,China [4]Institute of Reproductive and Stem Cell Engineering,NHC Key Laboratory of Human Stem Cell and Reproductive Engineering,School of Basic Medical Sciences,Central South University,Changsha,410008,China [5]Hunan International Scientific and Technological Cooperation base of Development and carcinogenesis,Changsha,410008,China [6]State Key Laboratory of Reproductive Medicine,The Affiliated Taizhou People’s Hospital of Nanjing Medical University,Taizhou School of Clinical Medicine,Nanjing Medical University,Nanjing,211166,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第2期351-354,共4页信号转导与靶向治疗（英文）

基　　金：This work was supported by the National Key Research and Development Program of China(2022YFC2702702 to M.L.and 2022YFC2702604 to Y.T.);the National Natural Science Foundation of China(32270899 and 32070842 to M.L.,82101961,82171608,82201773 and 81971447 to Y.T.);the Natural Science Foundation of Jiangsu Province(BK20190081 to M.L.);Changsha Municipal Natural Science Foundation(kq2202493 to S.Y.).We sincerely appreciate Zhuang Xiao and Shuqin Zhao from State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Chen Tan,Huan Zhang,Chaofeng Tu,Qinwei Zhou,Fei Meng,Qianjun Zhang,and Chunbo Xie from Reproductive and Genetic Hospital of CITIC-XIANGYA for their assistance in this study.

摘　　要：Dear Editor,Male subfertility,a multifactorial disease affecting~7%of the global male population,is usually caused by abnormalities in sperm flagella.The flagella and motile cilia have similar“9+2”axonemes and are evolutionarily conserved,being widely distributed in bacteria,archaea and eukaryotes1.Cilia defects also lead to primary ciliary dyskinesia(PCD),which affects approximately 1/10,000 individuals worldwide.

关 键 词：FERTILITY functional ASSEMBLY 

分 类 号：R339.21[医药卫生—人体生理学]