纯化Vero细胞狂犬病疫苗应用研究进展  

Research progress in application of purified Vero cell rabies vaccine

作　　者：随海田 郭昱 张倩 杨中楠 苏锦锋 张杨 殷文武[2] 舒祥 Sui Haitian;Guo Yu;Zhang Qian;Yang Zhongnan;Su Jinfeng;Zhang Yang;Yin Wenwu;Shu Xiang(China National Biotec Group,Beijing 100024,China;Division of Infectious Diseases of Chinese Center for Disease Control and Prevention,Beijing 102206,China)

机构地区：[1]中国生物技术股份有限公司,北京100024 [2]中国疾病预防控制中心传染病管理处,北京102206

出　　处：《中华实验和临床病毒学杂志》2023年第2期208-215,共8页Chinese Journal of Experimental and Clinical Virology

摘　　要：纯化Vero细胞狂犬病疫苗(purified Vero cell rabies vaccine,PVRV)在狂犬病预防中的应用已历经40余年。对近年来国内外PVRV在狂犬病预防中的相关研究进行综述显示,在简化的Zagreb免疫方案中,PVRV具有与在标准Essen方案中相似的免疫原性和安全性。PVRV与纯化鸡胚细胞狂犬病疫苗(purified chicken embryo cell rabies vaccine,PCECV)、人二倍体细胞狂犬病疫苗(human diploid cell rabies vaccine,HDCV)具有相似的免疫原性和安全性。在疾病等特殊人群中,PVRV也同样具有良好的免疫原性和安全性。此外,PVRV与吸附无细胞百白破灭活脊髓灰质炎联合疫苗(acellular diphtheria,tetanus,pertussis and inactivated poliomyelitis combined vaccine,DTP-IPV)等的联合接种并未发现免疫干扰现象,这为儿童在接种免疫规划疫苗同时进行狂犬病疫苗接种提供了可行性。PVRV与马狂犬病免疫球蛋白联合应用也可获得较好的预防效果。PVRV在预防狂犬病方面发挥着重要的作用,其广泛应用将为实现世界卫生组织提出的2030年消除犬传人狂犬病目标作出积极贡献。The purified Vero cell rabies vaccine(PVRV)has been used in rabies prevention for more than 40 years.A comprehensive review of the relevant researches on PVRV in rabies prevention at local and overseas in recent years shows that in the simplified Zagreb immunization program,PVRV has the similar immunogenicity and safety as in the standard Essen program.PVRV,purified chicken embryo cell rabies vaccine(PCECV)and human diploid cell rabies vaccine(HDCV)have similar immunogenicity and safety.PVRV also has good immunogenicity and safety in special populations such as those with diseases.The combined vaccination of PVRV and acellular diphtheria,tetanus,pertussis and inactivated poliomyelitis combined vaccine(DTP-IPV)or others did not find immune interference,which provided feasibility for children to vaccinate against rabies at the same time of vaccinating with planned vaccines.The combination of PVRV and equine rabies immunoglobulin can also achieve better prevention effect.PVRV plays an important role in the prevention of rabies,and its wide application will make a positive contribution to achieving the goal of eliminating rabies transmitted from dogs to humans by 2030 proposed by World Health Organization(WHO).

关 键 词：狂犬病 纯化Vero细胞狂犬病疫苗 安全性 免疫原性 

分 类 号：R392[医药卫生—免疫学]