高龄女性髋部骨折术后谵妄患者血清维生素D水平变化及意义  

Serum vitamin D level in elderly women with postoperative delirium after hip fracture surgery

作　　者：翟娟 刘艳红 宋星辰 翟怀远 衡科[2] 胡艳丽 李梅 崔瑶 薛魁 耿庆贺 郭依龙 ZHAI Juan;LIU Yanhong;SONG Xingchen;ZHAI Huaiyuan;HENG Ke;HU Yanli;LI Mei;CUI Yao;XUE Kui;GENG Qinghe;GUO Yilong(Central Laboratory,Pizhou Hospital Affiliated to Xuzhou Medical University,Xuzhou,Jiangsu 221300,China;不详)

机构地区：[1]徐州医科大学附属邳州医院中心实验室,江苏徐州221300 [2]南京医科大学附属常州二院骨科,江苏常州213161 [3]徐州医科大学肿瘤实验室,江苏徐州221000 [4]徐州医科大学附属邳州医院骨科,江苏徐州221300

出　　处：《中国临床研究》2023年第4期615-618,共4页Chinese Journal of Clinical Research

基　　金：中国博士后科学基金面上项目(2020M681739);江苏省卫健委医学科研项目(LKM2022048,Z2021221);江苏省重点实验室开放课题(XZSYSKF2020004);徐州医科大学校级科研课题(2018KJ23)。

摘　　要：目的探讨高龄女性髋部骨折术后谵妄(POD)患者血清25-羟维生素D浓度及其临床意义。方法选择2019年1月至2022年5月在徐州医科大学附属邳州医院骨科行髋部骨折手术治疗后发生POD的32例高龄女性患者为POD组,使用记忆谵妄评定量表(MDAS)评估谵妄的严重程度。另选取髋部骨折手术后未发生POD的高龄女性患者32例作为对照组。采用双抗体夹心酶联免疫吸附法(ELISA)检测血清25-羟维生素D水平,分析其与谵妄程度的相关性。结果POD组患者血清25-羟维生素D水平[(15.79±1.71)ng/mL]明显低于对照组[(31.40±2.91)ng/mL],差异有统计学意义(P<0.05)。25-羟维生素D与MDAS评分呈负相关(r=-0.803,P<0.01)。结论25-羟维生素D降低是高龄女性髋部骨折术后POD的危险因素,其血清浓度与谵妄程度负相关。高龄女性髋部骨折术前应检测血清25-羟维生素D浓度、补充维生素D,以预防POD的发生。Objective To investigate the serum 25-hydroxyvitamin D[25-(OH)D]concentration and its clinical significance in elderly women with postoperative delirium(POD)after hip fracture surgery.Methods From January 2019 to May 2022,32 elderly female patients who developed POD after hip fracture surgery in Pizhou Hospital Affiliated to Xuzhou Medical University were selected as POD group,for whom the memorial delirium assessment scale(MDAS)was used to assess the severity of POD.At the same time,32 elderly female patients without POD after hip fracture surgery were served as controls.By double-antibody sandwich enzyme-linked immunosorbent assay(ELISA),the levels of 25-(OH)D in two groups were detected.The correlation between the serum 25-(OH)D level and the degree of POD was analyzed.Results The serum level of 25-(OH)D in POD group was significantly lower than that in control group[(15.79±1.71)ng/mL vs(31.40±2.91)ng/mL,P<0.05],and the level of 25-(OH)D was negatively correlated with MDAS score(r=-0.803,P<0.01).Conclusion The low level of 25-(OH)D is a risk factor for POD in elderly women with hip fracture surgery,and the preoperative detection of serum 25-(OH)D concentration and vitamin D supplementation are effective in preventing POD of the patients.

关 键 词：髋部骨折 女性 高龄 术后谵妄 25-羟维生素D 

分 类 号：R619[医药卫生—外科学]