Banking of perinatal mesenchymal stem/stromal cells for stem cellbased personalized medicine over lifetime:Matters arising  

作　　者：Cheng-Hai Li Jing Zhao Hong-Yan Zhang Bin Wang 

机构地区：[1]Stem Cell Program of Clinical Research Center,People’s Hospital of Zhengzhou University and Henan Provincial People’s Hospital,Zhengzhou 450003,Henan Province,China [2]Department of Clinical Laboratory,People’s Hospital of Zhengzhou University and Henan Provincial People’s Hospital,Zhengzhou 450003,Henan Province,China [3]Department of Pharmacy,Fuwai Central China Cardiovascular Hospital,Zhengzhou 450000,Henan Province,China [4]Department of Neurosurgery,People’s Hospital of Zhengzhou University and Henan Provincial People’s Hospital,Zhengzhou 450003,Henan Province,China

出　　处：《World Journal of Stem Cells》2023年第4期105-119,共15页世界干细胞杂志（英文版）（电子版）

基　　金：Supported by the Henan Province Science and Technique Bureau R&D Project,No.222102310228.

摘　　要：Mesenchymal stromal/stem cells(MSCs)are currently applied in regenerative medicine and tissue engineering.Numerous clinical studies have indicated that MSCs from different tissue sources can provide therapeutic benefits for patients.MSCs derived from either human adult or perinatal tissues have their own unique advantages in their medical practices.Usually,clinical studies are conducted by using of cultured MSCs after thawing or short-term cryopreserved-then-thawed MSCs prior to administration for the treatment of a wide range of diseases and medical disorders.Currently,cryogenically banking perinatal MSCs for potential personalized medicine for later use in lifetime has raised growing interest in China as well as in many other countries.Meanwhile,this has led to questions regarding the availability,stability,consistency,multipotency,and therapeutic efficiency of the potential perinatal MSC-derived therapeutic products after longterm cryostorage.This opinion review does not minimize any therapeutic benefit of perinatal MSCs in many diseases after short-term cryopreservation.This article mainly describes what is known about banking perinatal MSCs in China and,importantly,it is to recognize the limitation and uncertainty of the perinatal MSCs stored in cryobanks for stem cell medical treatments in whole life.This article also provides several recommendations for banking of perinatal MSCs for potentially future personalized medicine,albeit it is impossible to anticipate whether the donor will benefit from banked MSCs during her/his lifetime.

关 键 词：Mesenchymal stromal/stem cells Adult mesenchymal stromal/stem cells Perinatal mesenchymal stromal/stem cells Perinatal tissue Stem cell bank Personalized medicine 

分 类 号：R95[医药卫生—药学]