Lymphocyte integrins mediate entry and dysregulation of T cells by SARS-CoV-2  

作　　者：Mengwen Huang Xingchao Pan Xinling Wang Qingfei Ren Bei Tong Xianchi Dong Gaoxiang Ge Lu Lu Shibo Jiang Jianfeng Chen 

机构地区：[1]Key Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,China [2]State Key Laboratory of Cell Biology,Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China [3]Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS),Shanghai Institute of Infectious Disease and Biosecurity,School of Basic Medical Sciences,Shanghai Frontiers Science Center of Pathogenic Microbes and Infection,Fudan University,Shanghai 200032,China [4]State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,Nanjing University,Nanjing 210023,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第3期916-920,共5页信号转导与靶向治疗（英文）

基　　金：This research was supported by the National Key R&D Program of China(2020YFA0509000 to J.C.);the National Natural Science Foundation of China(32030024,31830112,and 31525016 to J.C.,92169112 and 82161138002 to S.J.);Program of Shanghai Academic Research Leader(19XD1404200);Shanghai Municipal Science and Technology Major Project(ZD2021CY001 to S.J);National Ten Thousand Talents Program.The authors gratefully acknowledge the support of the SA-SIBS scholarship program.

摘　　要：Dear Editor,T-cell infection by SARS-CoV-2 and associated immune responses are correlated with disease severity and prognosis of COVID-19.Lymphopenia is associated with increased disease severity in COVID-19.Significantly lower circulating T and B cell counts were observed in patients who died from COVID-19 compared with survivors.Moreover,SARS-CoV-2 infection causes aberrant lymphocyte activation and dysfunction.

关 键 词：SEVERITY infection prognosis 

分 类 号：R392[医药卫生—免疫学]