补充维生素D对代谢综合征的影响:一项回顾性研究  

Effect of vitamin D supplementation on metabolic syndrome: a retrospective study

作　　者：杨婧[1] 王鑫[1] 王子惠[1] 于晓佳[1] 王华光[1] 朱莹[1] 李博宇[1] 邱爽[1] 安卓玲[1] Jing Yang;Xin Wang;Zihui Wang;Xiaojia Yu;Huaguang Wang;Ying Zhu;Boyu Li;Shuang Qiu;Zhuoling An(Department of Pharmacy,Beijing Chao-Yang Hospital,Capital Medical University,Beijing 100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院药事部,北京100020

出　　处：《Journal of Chinese Pharmaceutical Sciences》2023年第3期200-206,共7页中国药学（英文版）

摘　　要：补充维生素D可以改善代谢综合征相关指标。我们的研究希望找出对于25(OH)D水平低的患者,这种改善是否具有剂量依赖性。我们对2017年1月至2019年6月患有代谢综合征的患者进行了回顾性研究。根据25(OH)D的基本水平分为三组。1组和2组(血清25(OH)D <20 nmol/L)给予第一周口服维生素D2 80 000 IU,随后3周每周给予维生素D2 40 000 IU。3组血清25(OH)D为20–30 nmol/L,每周给予维生素D240 000 IU,口服4周。采用卡方检验、单因素方差分析和T检验的方法进行分析。结果发现,共111名患者纳入研究,平均年龄为62.21±13.35岁(21–89岁),平均血清25(OH)D为14.67±5.75 nmol/L(4.6–27.5 nmol/L)。在使用维生素D 29.92±2.72天后,各组血清25(OH)D显著升高(P <0.05)。收缩压、甘油三酯和低密度脂蛋白胆固醇显著降低(P <0.05),而总胆固醇和空腹血糖无明显降低。三组间收缩压、舒张压、总胆固醇、低密度脂蛋白胆固醇、甘油三酯差异无统计学意义(P>0.05)。增加25(OH)D水平可以减轻他汀类药物引起的疼痛,尽管他汀类基因的结果表明肌痛的风险很高。综上所述,补充维生素D对代谢综合征的患者有益,但尚未发现这种益处与补充维生素D的剂量有关。Vitamin D supplementation can improve metabolic syndrome(MetS)-related indicators.In the present study,we aimed to explore whether this improvement was dose-dependent in patients with low 25(OH)D levels.A retrospective study that recruited MetS patients from January 2017 to June 2019 was undertaken.They were divided into three groups according to the basic level of 25(OH)D.Chi-square test,one-way ANOVA,and T-test were used to examine the differences.A total of 111 patients were included in this study.The average age of them was 62.21±13.35 years(21–89 years),and the mean serum 25(OH)D was 14.67±5.75 nmol/L(4.6–27.5 nmol/L).After 29.92±2.72 d,the serum 25(OH)D of each group was significantly increased(P<0.05).The SBP,TG,and LDL-C were significantly decreased(P<0.05),while TC and FBG were unaffected.There was no difference between the three groups(P>0.05).Increasing the level of 25(OH)D could alleviate the pain caused by statins,even though the results of the statin gene suggested that the risk of myalgia was high.Taken together,vitamin D supplementation was beneficial for patients with MetS,and the benefit was not dose-related.

关 键 词：代谢综合征 维生素D 25(OH)D 

分 类 号：R977.24[医药卫生—药品]