固肾缩泉汤加减辅助治疗小儿遗尿症脾肾气虚证46例临床观察  

Clinical observation on 46 cases of modified Gushen Suoquan Tang(固肾缩泉汤)in adjuvant treatment of childhood enuresis with spleen and kidney qi deficiency syndrome

作　　者：张洁 王英枝[2] ZHANG Jie;WANG Yingzhi(Department of Pediatric Medicine,Yuyao Maternity and Child Health Care Hospital,Yuyao,Zhejiang,315400,China;The Outpatient Department,Taizhou Hospital in Zhejiang Province,Taizhou,Zhejiang,317000,China)

机构地区：[1]余姚市妇幼保健院小儿内科,浙江余姚315400 [2]浙江省台州医院门诊部,浙江台州317000

出　　处：《中医儿科杂志》2023年第2期75-79,共5页Journal of Pediatrics of Traditional Chinese Medicine

摘　　要：目的 观察固肾缩泉汤加减辅助治疗小儿遗尿症脾肾气虚证的临床疗效。方法 选取2020年1月至2021年1月余姚市妇幼保健院小儿内科收治的遗尿症脾肾气虚证患儿92例,按数字奇偶法分为治疗组和对照组,各46例。对照组口服醋酸去氨加压素片及行为治疗,治疗组在对照组治疗方法的基础上予固肾缩泉汤加减治疗。2组均2周为1个疗程,连续治疗4个疗程后,统计临床疗效,治疗前后中医证候积分、血清抗利尿激素(ADH)、每周遗尿次数及功能性膀胱容量,并随访3个月,统计复发率。结果 对照组总有效率为76.09%(35/46),治疗组为93.48%(43/46),2组比较,差异有统计学意义(P<0.05)。治疗前2组中医证候积分和血清ADH水平比较,差异均无统计学意义,具有可比性(P>0.05);治疗后2组中医证候积分显著降低,血清ADH水平显著升高,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组降低或升高更显著(P<0.05)。2组治疗前每周遗尿次数和功能性膀胱容量比较,差异均无统计学意义,具有可比性(P>0.05);治疗后2组每周遗尿次数明显减少,功能性膀胱容量明显增大,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组减少或增大更显著(P<0.05)。对照组复发率为20.00%(7/35),治疗组为7.14%(2/43),2组比较,差异有统计学意义(P<0.05)。结论 固肾缩泉汤加减辅助治疗小儿遗尿症脾肾气虚证,能促进血清ADH分泌,减少遗尿次数,增加膀胱容量,减少复发率,疗效显著,值得临床推广应用。Objective To observe the clinical efficacy of modified Gushen Suoquan Tang(固肾缩泉汤)in adjuvant treatment of childhood enuresis with spleen and kidney qi deficiency syndrome.Methods From January 2020 to January 2021,92 children of enuresis with spleen and kidney qi deficiency syndrome admitted into the Department of Pediatric Medicine in Yuyao Maternity and Child Health Care Hospital were divided into a treatment group and a control group according to the digital parity method,with 46 cases in each group.The control group was treated with oral desmopressin acetate tablets and behavioral therapy,while the treatment group was treated with modified Gushen Suoquan Tang on the basis of the treatment method of the control group.Both groups were treated for 2 weeks as a course of treatment.After 4 consecutive courses of treatment,the clinical efficacy,TCM syndrome scores,serum antidiuretic hormone(ADH),the number of enuresis and functional bladder volume before and after treatment were counted,and the recurrence rate was followed up for 3 months.Results The total effective rate was 76.09%(35/46)in the control group and 93.48%(43/46)in the treatment group.The difference between the two groups was statistically significant(P<0.05).Before treatment,there was no significant difference between the two groups in TCM syndrome scores and serum ADH levels,which was comparable(P>0.05);after treatment,the TCM syndrome scores of the two groups decreased significantly,and the serum ADH level increased significantly.Compared with the same group before treatment,the difference was statistically significant(P<0.05),and the treatment group decreased or increased more significantly(P<0.05).The number of enuresis and the functional bladder volume of the two groups before treatment were not statistically different and were comparable(P>0.05).After treatment,the number of enuresis was significantly reduced and the functional bladder volume was significantly increased in the two groups.Compared with the same group before treatment,the

关 键 词：小儿 遗尿症 脾肾气虚证 固肾缩泉汤 临床观察 

分 类 号：R272.6[医药卫生—中医儿科学]