河南辉县地区居民午睡习惯与心血管疾病发病风险的关联研究  

Study on the association of midday napping with risks of cardiovascular diseases incidence among Huixian resident in Henan Province

作　　者：孙花荣[1] 温俏睿 余灿清[2,3] 吕筠[2,3] 裴培 郭彧 陈铮鸣[5] 李立明[2,3] SUN Huarong;WEN Qiaorui;YU Canqing;LYV Jun;PEI Pei;GUO Yu;CHEN Zhengming;LI Liming(Huixian Center for Disease Control and Prevention,Xinxiang,Henan Province 453600,China;不详)

机构地区：[1]河南省辉县市疾病预防控制中心,河南省新乡453600 [2]北京大学公共卫生学院流行病与卫生统计学系 [3]北京大学公众健康与重大疫情防控战略研究中心 [4]中国医学科学院阜外医院国家心血管病中心,北京100037 [5]英国牛津大学临床与流行病学研究中心纳菲尔德人群健康系

出　　处：《中国慢性病预防与控制》2023年第3期213-217,共5页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：国家重点研发计划精准医学研究重点专项(2016YFC0900500);国家自然科学基金(82192900,82192901,82192904,81941018,91846303,91843302);中国香港Kadoorie Charitable基金。

摘　　要：目的了解河南辉县地区居民午睡习惯与心血管疾病(CVD)发病风险的关联,为该地区午睡习惯健康教育提供理论依据。方法数据来自中国慢性病前瞻性研究河南新乡辉县地区数据。在河南省辉县招募59866名30~79岁居民为研究对象。采用电子问卷调查研究对象的基本人口社会学特征、生活方式、疾病史、家族史、心理状态及睡眠行为等基线信息。通过多种途径进行随访,随访结局为诊断除非致死性高血压外的CVD、死亡、失访或到2017年12月31日为止。采用logistic回归(分类变量)和线性回归(连续变量)描述不同午睡习惯人群调整年龄和性别后的基线特征。使用Stata 15.0软件进行Cox比例风险回归分析,并进行亚组分析,分析交互作用。结果59866名研究对象中,73.7%有夏季午睡习惯,13.9%有常年午睡习惯。在平均随访(9.2±3.1)年期间,共确诊17142例CVD,CVD发病率为28.6%,累计粗发病密度为29.2/1000人年。多因素Cox回归分析结果显示,在调整多种潜在混杂因素后,与无午睡习惯者相比,有夏季午睡习惯者发生脑血管疾病的风险较高(HR=1.07),有常年午睡习惯者发生CVD、缺血性心脏病、脑血管疾病、缺血性卒中的风险均较高(HR值分别为1.11、1.12、1.15和1.14),均有统计学意义(P<0.05)。交互作用分析结果显示,年龄、性别可能对午睡与CVD关联存在效应修饰作用(P交互值分别为0.001和0.024),仅在年龄<65岁者(HR值分别为1.10和1.16)和女性(HR值分别为1.09和1.17)中发现夏季午睡及常年午睡与CVD发病风险增加有关。结论河南辉县地区居民常年午睡与CVD发病风险增加有关,午睡作为CVD可能的危险因素应得到进一步重视和关注。Objective To understand the association of daytime napping with risk of cardiovascular disease(CVD)incidence among Henan Huixian residents,and provide the theory basis for health education of daytime napping habit in this area.Methods The data were from Henan Xinxiang Huixian data of China Chronic Diseases Prospective Study,59866 residents(30-79 year old)in Henan Huixian served as the subjects.The investigation was performed with the electronic questionnaire(including sociodemographic characteristics,lifestyles,disease history,family history,mental state,and sleeping habits).The following-up was conducted by different ways,the following up outcome were the diagnosis of CVD(except for nonlethal hypertension),death,loss of following up or December 31,2017.Logistic regression(categorical variable)and linear regression continuous variables were used to describe the baseline characteristics after adjusting age and gender in residents with different midday napping habits.Cox proportional hazard regression was conducted.The sub-group analysis was performed to analyze the inter-reaction.The used software was Stata 15.0.Results Of 59866 subjects,73.7% of subjects had summer midday napping habit,13.9% of subjects had perennial midday napping habit.During a mean follow-up of 9.2±3.1 years,17142 cases of CVD were diagnosed,CVD incidence was 28.6%,and the crude cumulative incidence density was 29.2/1000 person-years.Multivariate cox regression analyses showed that after adjusting potential confounding factors,as compared with residents without midday napping habit,the residents with summer midday napping habit had the higher risk of CVD(HR=1.07),and the residents with perennial midday napping habit had the higher risk of CVD,ischemic heart diseases,cerebrovascular diseases and ischemic stroke(HR values were 1.11,1.12,1.15and 1.14),P<0.05.The inter-reaction analysis showed that age and gender had modified effect on association of midday napping with CVD(P values of inter-reaction were 0.001 and 0.024).In residents with 65 yea

关 键 词：午睡 心血管疾病 队列研究 

分 类 号：R54[医药卫生—心血管疾病]