HIV感染者合并新型冠状病毒感染情况调查  

Investigation on the infection with SARS-CoV-2 among people living with HIV

作　　者：韩晶 张晗希 李镇男 常珂 赵红心[3] HAN Jing;ZHANG Hanxi;LI Zhennan;CHANG Ke;ZHAO Hongxin(WHO Collaborating Centre for Comprehensive Management of HIV Treatment and Care,Beijing Ditan Hospital Capital Medical University,100015,China)

机构地区：[1]首都医科大学附属北京地坛医院WHO艾滋病治疗与关怀综合管理合作中心办公室,100015 [2]北京红丝带之家,100015 [3]首都医科大学附属北京地坛医院感染一科,100015

出　　处：《传染病信息》2023年第2期128-132,共5页Infectious Disease Information

基　　金：高层次公共卫生技术人才建设项目(2022-3-036);北京市自然基金-海淀原始创新联合基金(L222069);北京市医管中心项目登峰计划(DFL20191802);北京市医院管理局临床医学发展专项(ZYLX202126)。

摘　　要：目的分析HIV感染者的新型冠状病毒(新冠病毒)感染现状及康复情况,为全面总结HIV感染者合并新型冠状病毒感染的临床特征及预后提供依据。方法采用方便抽样方法,对2023年1月8—10日在北京地坛医院门诊就诊及随访微信群年龄≥18周岁的HIV感染者发放电子问卷,进行横断面调查分析。结果共收集电子问卷1247份,男性占94.1%、中位年龄为36.0(30.0,43.5)岁。自报告新冠病毒感染比例为88.5%,以轻型/普通型为主(95.7%)。HIV感染时长>10年,年龄≥50岁,普通型/重型,对症治疗/抗生素治疗以及服用抗新冠病毒药物治疗是康复时长>1周的危险因素;接种≥3针疫苗,最近1次CD4^(+)T细胞计数≥500为保护因素。结论本研究初步发现年龄,HIV感染时长,CD4^(+)T细胞计数,以及新冠病毒疫苗接种情况、临床表现类型、治疗方式等是新冠病毒感染后康复时长的可能影响因素,为今后在HIV感染者中开展新冠病毒感染情况的相关研究提供了一定的数据支持。Objective Analysis of the status and recovery of HIV-infected patients with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)to provide evidence for comprehensive summary of the clinical characteristics and prognosis of HIV-infected patients with SARS-CoV-2.Methods A convenience sampling method was used to conduct a cross-sectional survey analysis of HIV-infected patients aged≥18 years who attended outpatient clinic in Beijing Ditan Hospital and the follow-up WeChat group from January 8 to 10,2023,and the follow-up WeChat group who distributed and sent electronic questionnaires.Results A total of 1247 valid questionnaires were collected,94.1%were male,and the median age was 36.0(30.0,43.5)years old.The proportion of self-reporting SARS-CoV-2 infection was 88.5%,and 95.7%were mild and common type.HIV infection>10 years,age≥50 years old,and common type/severe type,symptomatic treatment/antibiotic treatment and treatment with SARS-CoV-2 antiviral drugs were risk factors for recovery duration of more than one week;≥3 doses of vaccine,and latest CD4^(+)T cell count≥500 were protective factors.Conclusions We preliminarily found that age,duration of HIV infection,CD4^(+)T cell count,as well as SARS-CoV-2 vaccination,clinical type,and treatment methods,are possible factors influencing the recovery time after SARS-CoV-2 infection,providing data support for future studies on HIV-infected patients with SARS-CoV-2.

关 键 词：艾滋病病毒 新型冠状病毒 共感染 横断面调查 流行病学特点 临床特点 治疗 疫情防控 

分 类 号：R512.91[医药卫生—内科学]