EPO、IL-1β、MMP-9/TIMP-1与烧伤患者瘢痕评分、创面愈合时间关系及对创面愈合质量的预测价值  

The Relationship of EPO,IL-1β,MMP-9/TIMP-1 with Scar Score,Wound Healing Time and Predictive Value of Wound Healing Quality in Burn Patients

作　　者：王之学[1] 肖继州[1] 于强[1] 杨书培 郭延民 WANG Zhixue;XIAO Jizhou;YU Qiang;YANG Shupei;GUO Yanmin(Department of Burn Surgery,Liaocheng Second People's Hospital,Liaocheng 252600,Shandong,China)

机构地区：[1]聊城市第二人民医院烧伤外科,山东聊城252600

出　　处：《中国美容医学》2023年第4期12-16,共5页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨促红细胞生成素(Erythropoietin,EPO)、白介素-1β(Interleukin-1β,IL-1β)、基质金属蛋白酶-9/基质金属蛋白酶抑制剂-1(Matrix metalloproteinase-9/Tissue inhibitor of metalloproteinase-1,MMP-9/TIMP-1)与烧伤患者瘢痕评分、创面愈合时间关系及对创面愈合质量的预测价值。方法:选取2018年5月-2021年1月笔者科室收治的113例深Ⅱ度烧伤患者,采用削痂植皮联合外用重组人粒细胞-巨噬细胞刺激因子治疗,根据创面愈合质量分为良好组(n=88)、不良组(n=25),比较两组基线资料及治疗前、治疗5 d、10 d后EPO、IL-1β、MMP-9/TIMP-1,应用Pearson分析治疗5 d、10 d后EPO、IL-1β、MMP-9/TIMP-1与温哥华瘢痕量表(Vancouver scar scale,VSS)、创面愈合时间关系,采用多因素Logistic回归方程分析创面愈合质量的相关影响因素,采用受试者工作特征曲线(Receiver operating characteristic,ROC)及ROC下面积(Area under the curve,AUC)分析治疗5 d、10 d后EPO、IL-1β、MMP-9/TIMP-1,预测创面愈合质量价值。结果:不良组创面愈合时间、VSS评分数值均高于良好组(P<0.05);不良组治疗5 d、10 d后EPO低于良好组,IL-1β、MMP-9/TIMP-1高于良好组,差异均有统计学意义(P<0.05);治疗5 d、10 d后EPO与VSS评分、创面愈合时间呈负相关(P<0.05);治疗5 d、10 d后IL-1β、MMP-9/TIMP-1与VSS评分、创面愈合时间呈正相关(P<0.05);将创面愈合时间、VSS评分控制后,治疗5 d、10 d后EPO、IL-1β、MMP-9/TIMP-1仍与创面愈合质量相关(P<0.05);治疗10 d后EPO、IL-1β、MMP-9/TIMP-1的AUC大于治疗5 d后,且EPO、IL-1β联合MMP-9/TIMP-1的AUC大于任一单一指标。结论:EPO、IL-1β、MMP-9/TIMP-1与烧伤患者瘢痕评分、创面愈合时间、创面愈合质量有关,联合检测能为临床预测创面质量提供有效参考,并有望成为促进创面愈合、提高愈合质量的一个干预靶点。Objective To investigate the relationship between erythropoietin(EPO),interleukin-1β(IL-1β),matrix metalloproteinase-9/matrix metalloproteinase inhibitor-1(MMP-9/TIMP-1)and scar scores of burn patients and the relationship between wound healing time and the predictive value of wound healing quality.Methods A total of 113 patients with deep second-degree burns admitted to our hospital from May 2018 to January 2021 were selected and treated with scab skin grafting combined with topical recombinant human granulocyte-macrophage stimulating factor.They were divided into good groups according to the quality of wound healing(n=88),poor group(n=25),compare the baseline data of the two groups,before treatment,5 days after treatment,and 10 days after treatment for EPO,IL-1β,MMP-9/TIMP-1,and Pearson analysis treatment 5 The relationship between EPO,IL-1β,MMP-9/TIMP-1 and Vancouver Scar Scale(VSS),wound healing time after 10 days of treatment,and the related influencing factors of wound healing quality analyzed by multivariate logistic regression equation.The receiver operating characteristic curve(ROC)and the area under the ROC(AUC)were used to analyze the value of EPO,IL-1β,MMP-9/TIMP-1 in predicting the quality of wound healing after 5 days of treatment and 10 days after treatment.Results The wound healing time and VSS score of the bad group were higher than those of the good group(P<0.05);the EPO of the bad group was lower than that of the good group after 5 days of treatment and 10 days after treatment,and IL-1βand MMP-9/TIMP-1 were higher than the good group,the differences were statistically significant(P<0.05);EPO was negatively correlated with VSS score and wound healing time after 5 days of treatment and 10 days of treatment(P<0.05);IL-1β,MMP-9/TIMP-1 was positively correlated with VSS score and wound healing time(P<0.05);after controlling the wound healing time and VSS score,EPO,IL-1β,MMP-9/TIMP-1 after 5 days of treatment and 10 days after treatment It is still related to the quality of wound healing(P<0

关 键 词：EPO IL-1Β MMP-9/TIMP-1 烧伤 VSS评分 创面愈合时间 创面愈合质量 

分 类 号：R622[医药卫生—整形外科]