碱性成纤维细胞生长因子联合Meek植皮术修复严重烧伤创面的效果及皮片存活危险因素分析  

Effect of Basic Fibroblast Growth Factor Combined with Meek Skin Grafting on Severe Burn Wounds and Skin Survival Risk Factors Analysis

作　　者：梁显南 颜帅 LIANG Xiannan;YAN Shuai(Department of Burn and Plastic Surgery,Sanya Central Hospital,Sanya 572000,Hainan,China)

机构地区：[1]三亚市中心医院烧伤整形科,海南三亚572000

出　　处：《中国美容医学》2023年第4期22-25,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:分析严重烧伤患者碱性成纤维细胞生长因子联合Meek植皮术后皮片存活情况及影响皮片存活的危险因素。方法:将128例严重烧伤患者分为两组,对照组(64例)采用Meek植皮术,观察组(64例)采用碱性成纤维细胞生长因子联合Meek植皮术,分析患者的创面修复效果、VAS评分;根据术后7d皮片存活率又将观察组患者分组,分析其术前实验室指标及影响皮片存活的危险因素。结果:术后,观察组患者的创面愈合时间短于对照组、VAS评分低于对照组,术后7d皮片存活率、总有效率高于对照组,差异均有统计学意义(P<0.05)。术前,皮片存活良好组的血红蛋白(HB)、中性粒细胞(NEUT)、白蛋白(ALB)水平与存活不良组相比,差异无统计学意义(P>0.05);而其血小板(PLT)水平明显高于存活不良组(P<0.05)。Logistic回归分析,术前PLT为术后皮片存活的独立危险因素(P<0.05)。结论:碱性成纤维细胞生长因子联合Meek植皮术能有效提高严重烧伤患者的皮片存活率,可在临床推广使用;术前PLT为术后皮片存活的独立危险因素,但该研究病例数较少,数据存在一定不足。Objective To analyze the skin survival and risk factors after alkaline fibroblast growth factor combined with Meek skin grafting in severe burn patients.Methods A total of 128 severe burn patients were divided into two groups.The control group(64 cases)was treated with Meek skin grafting,and the observation group(64 cases)was treated with alkaline fibroblast growth factor combined with Meek skin grafting.The wound healing effect,effcacy and VAS score of the patients were analyzed.Patients in the observation group were divided into groups according to the skin film survival rate 7 days after operation,and the preoperative laboratory indicators and risk factors affecting skin film survival were analyzed.Results After surgery,the skin healing time,wound healing time and VAS score in the observation group were significantly lower than those in the control group,and the skin survival rate and total effective rate 7 days after surgery were significantly higher than those in the control group(P<0.05).Before surgery,the levels of HB,NEUT andALB in the good skin survival group were not significantly different from those in the poor skin survival group(P>0.05).The PLT level was significantly higher than that of poor survival group(P<0.05).Logistic regression analysis showed that preoperative PLT was an independent risk factor for postoperative skin survival(P<0.05).Conclusion Basic fibroblast growth factor combined with Meek skin grafting can effectively improve the survival rate of skin grafts in severe burn patients,and can be used in clinical practice.Preoperative PLT was an independent risk factor for postoperative skin graft survival,but the number of cases in this study was small and the data were insuffcient.

关 键 词：严重烧伤 MEEK植皮术 皮片 碱性成纤维细胞生长因子 危险因素 

分 类 号：R622[医药卫生—整形外科]