夫西地酸治疗浅Ⅱ度烧伤的疗效及对烧伤常见菌的体外抗菌活性探讨  

To Investigate the Effi cacy of Fusidic Acid in the Treatment of Superfi cial Partial-Thickness Burns and Its in Vitro Antibacterial Activity Against Common Burn Bacteria

作　　者：王廷宇 叶子青 郭晓雨 谢卫国 WANG Tingyu;YE Ziqing;GUO Xiaoyu;XIE Weiguo(Department of Burn,Wuhan University Tongren Hospital(Wuhan Third Hospital),Wuhan 430074,Hubei,China)

机构地区：[1]武汉大学同仁医院暨武汉市第三医院烧伤科,湖北武汉430074

出　　处：《中国美容医学》2023年第4期34-37,共4页Chinese Journal of Aesthetic Medicine

基　　金：重大疾病防治科技行动计划(编号:2018ZX-01S-001);武汉市卫生与计划生育委员会科研项目(编号:WX18Q44)。

摘　　要：目的:检测夫西地酸对烧伤常见菌的体外抗菌活性并观察夫西地酸治疗浅Ⅱ度烧伤的临床效果。方法:采用琼脂扩散法比较夫西地酸乳膏和磺胺嘧啶银软膏对耐甲氧西林的金黄色葡萄球菌(MRSA)、金黄色葡萄球菌(Sau)、表皮葡萄球菌(Sep)、铜绿假单胞菌(Pae)、大肠杆菌(Eco)的体外抗菌活性。选择2021年12月-2022年4月就诊的84例小面积浅Ⅱ度烧伤患者随机分为两组,使用夫西地酸乳膏治疗的42例患者为观察组;使用磺胺嘧啶银软膏治疗的42例患者为对照组,药物使用直至两组创面上皮化愈合。分别记录两组患者的创面愈合时间、1周创面愈合率、疼痛程度、分泌物培养阳性率、不良反应发生率。结果:体外实验中夫西地酸乳膏对MRSA、Sau、Sep的抑菌圈均大于磺胺嘧啶银软膏,差异有统计学意义(P<0.05)。临床观察中观察组创面完全愈合时间短于对照组(P<0.05);观察组前3次用药后疼痛程度评分均小于对照组(P<0.05);两组患者1周创面愈合率、使用药物前及使用药物后2~3?d、5~6d创面分泌物培养阳性率结果比较,差异均无统计学意义(P>0.05);两组患者不良反应比较差异无统计学意义(P>0.05)。结论:夫西地酸乳膏对烧伤常见阳性菌如MRSA、Sau、Sep有较强抗菌效果,治疗浅Ⅱ度烧伤可有效防治创面感染,促进创面愈合,缓解患者换药疼痛程度。Objective To detect the in vitro antibacterial activity of fusidic acid against common burn bacteria and to observe the clinical effects of fusidic acid in the treatment of superficial second-degree burns.Methods Experimental study.Comparison of in vitro antibacterial activity of fusidic acid and silver sulfadiazine against methicillin-resistant Staphylococcus aureus(MRSA).Staphylococcus aureus(Sau),Staphylococcus epidermidis(Sep),Pseudomonas aeruginosa(Pae),and Escherichia coli(Eco)using agar diffusion method.Clinical observation:84 patients with small superficial second-degree bums who presented to our outpatient clinic between December 2021 and April 2022 were included and randomly divided into 2 groups of 42 patients each.Those treated with fusidic acid were used as the observation group,those treated with silver sulfadiazine were used as the control group until the epithelialization of the wounds healed in both groups.The wound healing time,one-week wound healing rate,pain level,positive secretion culture rate,and incidence of adverse reactions were recorded in the two groups,respectively.Results In vitro experimental results:the inhibition circle of fusidic acid cream on MRSA,Sau and Sep were greater than that of silver sulfadiazine cream,and the difference was statistically significant(P<0.05).In clinical observation,the complete wound healing time of the observation group was shorter than that of the control group(P<0.05).The pain degree scores of the observation group were lower than those of the control group after the first three times of medication(P<0.05).The results of one week wound healing rate,positive wound secretion culture rate before and(2-3)d and(5-6)d after the use of drugs in the 2 groups were not statistically significant(P>0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Fusidic acid cream has a strong antibacterial effect on burn common positive bacteria such as MRSA,Sau and Sep.Treatment of superficial Ⅱ burns can effectively pr

关 键 词：夫西地酸 烧伤 浅Ⅱ度烧伤 感染 创面愈合 抗菌活性 

分 类 号：R622[医药卫生—整形外科]