重组牛碱性成纤维细胞生长因子对面部凹陷性瘢痕超脉冲点阵CO_(2)激光治疗后皮损的修复作用分析  

Analysis of the Effect Of Recombinant Bovine Basic Fibroblast Growth Factor On Skin Repair after Ultra-pulse Fractional CO_(2) Laser Treatment of Facial Depressed Scar

作　　者：王华清 殷娜 WANG Huaqing;YIN Na(Department of Cosmetology,Rizhao Dermatology Prevention and Treatment Institut,Rizhao 276800,Shandong,China;Facial Care Room,Rizhao Dermatology Prevention and Treatment Institut,Rizhao 276800,Shandong,China)

机构地区：[1]山东省日照市皮肤病防治所美容科,山东日照276800 [2]山东省日照市皮肤病防治所面部护理室,山东日照276800

出　　处：《中国美容医学》2023年第4期92-95,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:观察外用重组牛碱性成纤维细胞生长因子(Recombinant bovine basic fibroblast growth factor,rbbFGF)对面部凹陷性瘢痕超脉冲点阵CO_(2)激光治疗后皮损的修复作用。方法:采用随机数字表法将2018年9月-2020年9月笔者医院收治的136例面部凹陷性瘢痕患者分为观察组和对照组,每组68例。两组患者均给予超脉冲点阵CO_(2)激光治疗,对照组患者术后给予外用金霉素软膏,观察组患者术后外用rb-bFGF。比较两组患者临床疗效、治疗后相关指标(红斑持续时间、结痂时间、疼痛持续时间),观察治疗前、治疗3个疗程后两组患者皮损情况(Echelle d’evaluation clinique des cicatrices d’acne,ECCA)、皮肤生理指标(毛孔、面部红色区、紫质、棕色斑)、血清炎性因子肿瘤坏死因子、白细胞介素-6、白细胞介素-8、白细胞介素-1β变化情况。结果:观察组患者临床总有效率明显高于对照组,观察组患者红斑持续时间、结痂时间、疼痛持续时间均短于对照组,差异均有统计学意义(P<0.05);治疗3个疗程后,两组患者ECCA评分、皮肤生理指标及血清炎性因子水平均低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。结论:外用rb-bFGF对面部凹陷性瘢痕超脉冲点阵CO_(2)激光治疗后皮损的修复疗效显著,能有效改善患者皮肤生理状态,缩短皮损好转时间,降低血清炎症因子水平。Objective To observe the effcacy of topical recombinant bovine basic fibroblast growth factor(rb-bFGF)on ultra-pulse fractional CO_(2) laser treatment of facial depressed scar.Methods 136 patients facial depressed scar treated in the hospital between September 2018 and September 2020 were divided into observation group and control group according to the random number table method,with 68 cases in each group.The patients in the two groups were treated with ultra-pulse fractional CO_(2) laser,and the patients in the control group were treated with chlortetracycline ointment after surgery,and the patients in the observation group were given topical rb-bFGF after surgery.The clinical effcacy and related indicators after treatment(erythema duration,crusting time,pain duration)were compared between the two groups.The skin lesions[Echelle d’Evaluation Clinique des Cicatrices d’acne(ECCA)],skin physiological indicators(pores,facial red areas,sclererythrin,brown spots)and serum inflammatory factors[tumor necrosis factor(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8),interleukin-1β(IL-1β)]of the two groups were observed before treatment and after 3 courses of treatment.Results The total clinical effective rate of observation group was significantly higher than that of control group(P<0.05).The erythema duration,crusting time and pain duration in observation group were shorter than those in control group(P<0.05).After 3 courses of treatment,the ECCAscore and levels of skin physiological indicators and serum inflammatory factors of the two groups of patients were lower than those before treatment,and the score and levels of observation group were lower than those of control group(P<0.05).Conclusion Topical rb-bFGF has a significant effcacy on ultra-pulse fractional CO_(2) laser treatment of facial depressed scar.It can effectively improve the skin physiological status,shorten the rash improvement time,and reduce the levels of serum inflammatory factors.

关 键 词：凹陷性瘢痕 重组牛碱性成纤维细胞生长因子 超脉冲点阵CO_(2)激光 皮损情况 炎性因子水平 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]