不同间充质干细胞及外泌体治疗宫腔粘连的研究进展  

Advanced treatment progress for intrauterine adhesion with different mesenchymal stem cells and exosomes

作　　者：叶红娟 石丽雅 全心馨 薛松果 YE Hong-juan;SHI Li-ya;QUAN Xin-xin;XUE Song-guo(Department of Reproductive Medicine,Shanghai East Hospital,Tongji University School of Medicine,Shanghai200120)

机构地区：[1]同济大学附属东方医院生殖医学中心,上海200120

出　　处：《生殖医学杂志》2023年第5期793-797,共5页Journal of Reproductive Medicine

基　　金：国家自然科学基金面上项目(82171691)。

摘　　要：宫腔粘连(IUA)是一种子宫内膜损伤性疾病,严重影响育龄期妇女生殖健康,已成为子宫性不孕因素的首要病因。目前尚无有效的治愈IUA的方法。间充质干细胞(MSCs)治疗作为一种新的再生医学细胞治疗方法,主要通过归巢到损伤部位后分化为子宫内膜细胞、调节宫腔免疫环境、抑制上皮间质转化、抗纤维化、调控子宫局部的MSCs增殖和迁移等作用,对子宫内膜再生和修复产生影响。MSCs旁分泌的外泌体主要通过促进细胞增殖、抑制细胞凋亡、抗炎和免疫调节功能、促进新生血管形成等作用修复子宫内膜。因此,本文针对IUA的研究现状、MSCs及外泌体对IUA的作用及机制的研究进展进行综述。Intrauterine adhesion(IUA)is a endometrial injury disease,which has seriously affected the reproductive health of women,and become the primary factor of uterine infertility.However,up to date,there is no effective treatment of IUA.Mesenchymal stem cell(MSCs)therapy,as a new regenerative medical cell therapy,mainly affects the regeneration and repair of endometrium by homing to the injured site and differentiating into endometrial cells,regulating the immune environment of the uterine cavity,inhibiting epithelial mesenchymal transformation,and regulating the proliferation and migration of MSCs in the uterus.Exosomes derived from MSCs mainly repair the endometrium by promoting cell proliferation,inhibiting apoptosis,anti-inflammatory and immunomodulatory and pro-angiogenic effect.In this paper,the research status of IUA,the role and mechanism of MSCs and exosomes on IUA are reviewed.

关 键 词：间充质干细胞 外泌体 宫腔粘连 

分 类 号：R711.7[医药卫生—妇产科学]