穴位埋线联合西药治疗稳定期慢性阻塞性肺疾病的疗效观察及对血清炎性因子水平的影响  

Efficacy observation of catgut-embedding therapy plus Western medication for stable chronic obstructive pulmonary disease and its effects on serum inflammatory factors levels

作　　者：杨歌 易安娜 周蕾 YANG Ge;YI Anna;ZHOU Lei(Zhejiang Chinese Medical University,Hangzhou 310000,China;Jinhua Hospital of Traditional Chinese Medicine,Zhejiang Chinese Medical University,Jinhua 321000,China)

机构地区：[1]浙江中医药大学,杭州310000 [2]浙江中医药大学附属金华中医院,金华321000

出　　处：《上海针灸杂志》2023年第5期439-444,共6页Shanghai Journal of Acupuncture and Moxibustion

基　　金：浙江省教育厅一般科研项目(Y202145957);浙江省金华市重大科学技术研究计划项目(2021-3-143)。

摘　　要：目的 观察穴位埋线联合西药治疗稳定期慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)的临床疗效及对血清炎性因子水平的影响。方法 将80例稳定期COPD患者随机分为观察组(37例,脱落3例)和对照组(38例,脱落2例)。对照组给予西药三联疗法(噻托溴铵粉雾剂联合沙美特罗替卡松气雾剂吸入治疗),观察组在对照组基础上联合穴位埋线治疗。观察两组治疗前后肺功能指标[1 s用力呼气容积(forced expiratory volume in one second, FEV1)、FEV1/用力肺活量(forced vital capacity, FVC)和COPD评估测试(COPD assessment test, CAT)评分]及白介素-6(interleukin-6, IL-6)水平、肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)水平、白细胞(white blood cell, WBC)计数、中性粒细胞(neutrophils, NEUT)数和红细胞沉降率(erythrocyte sedimentation rate, ESR)水平变化,并比较两组临床疗效。结果 观察组总有效率为86.5%,优于对照组的63.2%(P<0.05);观察组控显率为70.3%,优于对照组的36.8%(P<0.05)。治疗后,两组FEV1均升高(P<0.05),且观察组高于对照组(P<0.05);两组FEV1/FVC均升高(P<0.05),且观察组高于对照组(P<0.05);两组治疗后CAT评分均降低(P<0.05),且观察组低于对照组(P<0.05);两组IL-6水平、TNF-α水平、WBC计数、NEUT数和ESR降低(P<0.05),且观察组低于对照组(P<0.05)。结论 穴位埋线联合西药可降低稳定期COPD患者IL-6水平、TNF-α水平、WBC计数、NEUT数和ESR,显著改善FEV1、FEV1/FVC水平,降低CAT评分,优于单纯西药治疗。Objective To observe the clinical efficacy of catgut-embedding therapy combined with Western medication in treating stable chronic obstructive pulmonary disease(COPD)and its effects on serum inflammatory factors levels.Method Eighty patients with stable COPD were randomized into an observation group(37 cases,including 3 dropouts)and a control group(38 cases,including 2 dropouts).The control group was given triple therapy(Tiotropium bromide inhalation powder plus Salmeterol xinafoate and fluticasone propionate inhalation powder);based on which the observation group received additional catgut-embedding therapy.Before and after the treatment,the pulmonary function indexes such as the forced expiratory volume in one second(FEV1),FEV1/forced vital capacity(FVC)and COPD assessment test(CAT),and the levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α),white blood cell(WBC)count,neutrophils(NEUT)count,and erythrocyte sedimentation rate(ESR)were observed for the two groups.The clinical efficacy was also compared between the two groups.Result The total effective rate was 86.5%in the observation group,which surpassed 63.2%in the control group(P<0.05);the control plus the markedly effective rate was 70.3%in the observation group,which outperformed 36.8%in the control group(P<0.05).After the intervention,the FEV_(1) increased in both groups(P<0.05)and was higher in the observation group than in the control group(P<0.05);the FEV_(1)/FVC increased in both groups(P<0.05)and was higher in the observation group than in the control group(P<0.05);the CAT score dropped in both groups(P<0.05)and was lower in the observation group than in the control group(P<0.05);the levels of IL-6 and TNF-α,WBC count,NEUT count,and ESR dropped in both groups(P<0.05)and were lower in the observation group than in the control group(P<0.05).Conclusion Catgut-embedding therapy plus Western medication can reduced the levels of IL-6 and TNF-α,WBC count,NEUT count,and ESR and can significantly improve the FEV_(1) and FEV_(1)/FVC levels and re

关 键 词：埋藏疗法 埋线 肺疾病 慢性阻塞性 稳定期 三联疗法 

分 类 号：R246.1[医药卫生—针灸推拿学]