两种抗生素联合治疗老年晚期潜伏梅毒的临床疗效研究  

Clinical efficacy of ceftriaxone sodium combined with penicillin G benzathine in the treatment of late latent syphilis of the elderly

作　　者：闫宁[1] 刘文丽 于晓云[1] 李子海[1] 陈斌[3] YAN Ning;LIU Wenli;YU Xiaoyun;LI Zihai;CHEN Bin(Department of Dermatology,Nanjing Second Hospital,Nanjingg 210003,China;Department of Dermatology,Nanjing Luhe People's Hospital,Nanjing 211500,China;Department of Dermatology and Sexually Transmitted Dieases,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京市第二医院皮肤科,江苏南京210003 [2]南京市六合区人民医院皮肤科,江苏南京211500 [3]南京医科大学附属第一医院皮肤性病科,江苏南京210029

出　　处：《临床皮肤科杂志》2023年第5期263-265,共3页Journal of Clinical Dermatology

摘　　要：目的:探讨头孢曲松钠联合苄星青霉素治疗老年晚期潜伏梅毒的临床疗效。方法:根据治疗方案不同,将我科治疗的176例老年晚期潜伏梅毒患者分观察组(头孢曲松钠联合苄星青霉素)85例和对照组(单纯苄星青霉素)91例,比较两组患者1年后血清RPR及脑脊液检测结果转归情况。结果:观察组1年后21.18%患者血清RPR转阴,48.24%血清RPR下降≥2个滴度,30.59%血清RPR不变;对照组1年后12.09%患者血清RPR转阴,36.26%血清RPR下降≥2个滴度,51.54%血清RPR不变。两组治疗前后脑脊液检测结果均无明显差异。结论:头孢曲松钠联合苄星青霉素治疗老年晚期潜伏梅毒患者血清RPR转阴率与单用苄星青霉素无差异,但总有效率优于后者,值得临床推广。Objective:To investigate the clinical efficacy of ceftriaxone sodium combined with penicillin G benzathine in the treatment of elderly patients with late latent syphilis.Methods:One hundred and seventy-six elderly patients with late latent syphilis treated in our department were included in the study.These patients were divided into two groups:the observation group that had85 patients and were treated with ceftriaxone sodium combined with penicillin G benzathine,and the control group that had 91patients and were treated with penicillin G benzathine only.The serum rapid plasma reagin(RPR)and cerebrospinal fluid(CSF)were measured,and the results were compared before and one year after treatment.Results:One year after treatment,in the observation group,21.18%of the patients showed negative serum RPR,48.24%of the patients showed decreased serum RPR by more than or equal to 2 titers,and 30.59%of the patients showed unchanged RPR.In the control group,12.09%of the patients showed negative serum RPR,36.26%of the patients showed decreased serum RPR by more than or equal to 2 titers,and 51.54%of the patients showed unchanged RPR.There was no significant difference in CSF test results between the two groups before and after treatment.Conclusion:While there was no significant difference in the rate of the negative conversion between the two groups,the total effective rate of ceftriaxone sodium combined with penicillin G benzathine in the treatment of late latent syphilis of the elderly is significantly higher than that of penicillin G benzathine alone,using the serum RPR as a measurement.This combined therapy is worthy of clinical consideration.

关 键 词：梅毒 潜伏 晚期 老年 头孢曲松钠 苄星青霉素 

分 类 号：R759.12[医药卫生—皮肤病学与性病学]