无偿献血志愿者丙氨酸转氨酶升高影响因素分析  

Analysis of factors influencing the elevated ALT in volunteers who participated in blood donation

作　　者：程慢慢 王丹丹 马文静[2] CHENG Manman;WANG Dandan;MA Wenjing(Department of Blood Supply,Shangqiu Central Blood Station,Shangqiu 476000,China;Blood Sampling Center of Blood Sampling Department,Shangqiu First People's Hospital,Shangqiu 476000,China)

机构地区：[1]商丘市中心血站供血科,河南商丘476000 [2]商丘市第一人民医院采血科采血中心,河南商丘476000

出　　处：《社区医学杂志》2023年第6期320-323,共4页Journal Of Community Medicine

摘　　要：目的 分析无偿献血志愿者丙氨酸转氨酶(ALT)升高的影响因素及干预策略。方法 选取2021-02-01-2022-06-30商丘市中心血站674例无偿献血志愿者为研究对象,根据ALT水平分为ALT正常组(596例,ALT≤40 U/L)和ALT升高组(78例,ALT>40 U/L)。收集并比较2组临床资料,采用logistic多因素回归模型分析无偿献血志愿者ALT升高的影响因素。结果 ALT升高组男性占比78.21%,高于ALT正常组的52.35%,χ^(2)=18.658,P<0.001;肥胖占比28.21%,高于ALT正常组的8.72%,χ^(2)=26.780,P<0.001;有饮酒史占比28.21%,高于ALT正常组的10.57%,χ^(2)=19.463,P<0.001;长期熬夜占比37.18%,高于ALT正常组的11.91%,χ^(2)=34.849,P<0.001;三酰甘油(TG)为(2.52±0.34) mmol/L,高于ALT正常组的(1.07±0.33) mmol/L,t=36.364,P<0.001;总胆固醇(TC)为(5.81±1.14) mmol/L,高于ALT正常组的(4.13±0.71) mmol/L,t=18.084,P<0.001;血糖(FBG)为(4.79±0.65) mmol/L,高于ALT正常组的(3.20±0.58) mmol/L,t=22.441,P<0.001。logistic回归分析结果显示,男性(OR=6.174,95%CI为2.189~17.415)、肥胖(OR=7.683,95%CI为5.339~11.057)、有饮酒史(OR=5.698,95%CI为1.671~19.432)、长期熬夜(OR=6.626,95%CI为3.635~12.077)、TG水平(OR=8.441,95%CI为4.254~16.748)、TC水平(OR=6.767,95%CI为2.931~15.625)、FBG水平(OR=9.659,95%CI为5.013~18.611)是无偿献血志愿者ALT水平升高的危险因素,均P<0.001。结论 无偿献血志愿者ALT水平升高与性别、肥胖、有饮酒史、长期熬夜、TG、TC、FBG水平有关,应积极制定相关干预策略,以降低血液报废率。Objective To analyse the factors affecting the elevation of alanine aminotransferase(ALT) in volunteers who voluntarily donate blood and the intervention strategies.Methods Totally 674 unpaid blood donors from Shangqiu Central Blood Station from February 1,2021 to June 30,2022 were selected as the study subjects.According to the ALT level,they were divided into normal ALT group(596 cases,ALT≤40 U/L) and elevated ALT group(78 cases,ALT>40 U/L).The clinical data of the two groups were collected and compared,and the influencing factors of ALT elevation were analyzed in unpaid blood donation volunteers using logistic regression model.Results The proportion of males in the ALT elevation group(78.21 % vs 52.35%,χ^(2)=18.658),obesity(28.21 % vs 8.72%,χ^(2)=26.780),history of alcohol consumption(28.21% vs 10.57%,χ^(2)=19.463),staying up late for a long time(37.18% vs 11.91%,χ^(2)=34.849),triglycerides(TG) [(2.52±0.34) vs(1.07±0.33) mmol/L,t=36.364],total cholesterol(TC) [(5.81±1.14) vs(4.13±0.71)mmol/L,t=18.084],and blood glucose(FBG) [(4.79±0.65) vs(3.20±0.58) mmol/L,t=22.441] were higher than those in the ALT-normal group,with statistically significant differences(all P<0.001).Logistic regression analysis showed that male(OR=6.174,95 %CI:2.189-17.415),obesity(OR=7.683,95 % CI:5.339-11.057),history of alcohol consumption(OR=5.698,95% CI:1.671-19.432),staying up late for a long time(OR=6.626,95%CI:3.635-12.077),TG level(OR=8.441,95%CI:4.254-16.748),TC level(OR=6.767,95%CI:2.931-15.625) and FBG level(OR=9.659,95%CI:5.013-18.611) were the risk factors for the increase in ALT level in the non-remunerated volunteers risk factors for elevated levels(all P<0.001).Conclusion The increase of ALT level in unpaid blood donation volunteers is related to sex,obesity,drinking history,long-term staying up late,TG,TC and FBG levels.Relevant intervention strategies should be actively developed to reduce the rate of blood abandonment.

关 键 词：无偿献血 丙氨酸转氨酶 影响因素 干预策略 

分 类 号：R193.3[医药卫生—卫生事业管理]