药源性急性间质性肾炎的临床研究进展  

Advances in clinical research on drug-induced acute interstitial nephritis

作　　者：张明康 马彦荣[1,3] 靳永文 周燕 崔睿睿[1,2,3] 武新安 ZHANG Mingkang;MA Yanrong;JIN Yongwen;ZHOU Yan;CUI Ruirui;WU Xin'an(Department of Pharmacy,First Hospital of Lanzhou University,Lanzhou 730000,Gansu,China;School of Pharmacy,Lanzhou University,Lanzhou 730020,Gansu,China;Engineering Research Centre of Prevention and Control Risk for Clinical Medicine of Gansu Province,Lanzhou 730000,Gansu,China)

机构地区：[1]兰州大学第一医院药剂科,甘肃兰州730000 [2]兰州大学药学院,甘肃兰州730020 [3]甘肃省临床用药风险防控工程研究中心,甘肃兰州730020

出　　处：《中国临床药理学与治疗学》2023年第4期419-428,共10页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金资助项目(82060676,81960680,U21A20424);甘肃省科技计划项目(重大项目)(21ZD4FA014);兰州市城关区科技计划项目(2019RCCX0039)。

摘　　要：肾脏作为药物的主要排泄器官之一,当药物使用不当并未能得到有效排泄时,将导致其蓄积于肾脏或肾小管间质中,进而引起药源性肾损伤。肾小管间质占肾脏体积的80%,并且是对各种肾损伤做出反应的主要部位。本文主要关注药源性急性间质性肾炎,着重介绍其临床症状、列举常见诱导药物、分析病理学特征,并从免疫反应角度解释其发病机制,旨在为后续研究提供基础和临床依据。The kidneys are one of the main excretory organs for drugs and when drugs are not excreted effectively,they can accumulate in the kidneys or in the interstitial tubules,leading to druginduced kidney injury.The tubulointerstitium accounts for 80%of the volume of the kidney and is the primary site of response to various types of renal injury.This article focuses on drug-induced acute interstitial nephritis,highlighting its clinical symptoms, listing common induction drugs, analysingpathological features, and explaining its pathogenesisfrom the perspective of immune response,with the aim of providing a basic and clinical evidencefor subsequent studies.

关 键 词：药源性急性间质性肾炎 临床症状 诱导药物 病理学特征 发病机制 

分 类 号：R692.3[医药卫生—泌尿科学]