Gasdermin D蛋白的研究进展  

Research progress of Gasdermin D

作　　者：李陈广 麦凤怡 梁靖蓉 肖礼祖 张治国 LI Chen-guang;MAI Feng-yi;LIANG Jing-rong;XIAO Li-zu;ZHANG Zhi-guo(Shenzhen University Health Science Center School of Biomedical Engineering,Shenzhen 518060,China;Pain Management,Huazhong University of Science and Technology Union Shenzhen Hospital,Shenzhen 518052,China;Dept of Medicine,Southern University of Science and Technology,Shenzhen 518055,China)

机构地区：[1]深圳大学医学部生物医学工程学院,广东深圳518060 [2]华中科技大学协和深圳医院疼痛科,广东深圳518052 [3]南方科技大学医学院,广东深圳518055

出　　处：《中国药理学通报》2023年第5期817-822,共6页Chinese Pharmacological Bulletin

基　　金：中国博士后基金面上项目(No 2021M692207,2021M702276);深圳市南山区科技计划项目(No NS2021058,NS2021085)。

摘　　要：细胞焦亡作为一种新的程序性的炎症性坏死,与微生物感染和自身免疫性疾病等密切相关。而近年来才发现,Gasdermin D是细胞焦亡的执行蛋白,其切割会导致细胞膜上形成孔洞,诱导细胞焦亡发生,释放IL-1β和IL-18等炎性因子,加剧炎症反应的发生。随着对Gasdermin D研究的深入,逐渐明确了其蛋白结构以及活化位点,并进一步发现其除能被炎症小体激活外的其他活化途径。Gasdermin D的活化能够诱导细胞膜孔洞的形成并调节炎症因子的分泌,但并不一定意味着细胞的死亡,这些研究的发现让我们更深入了解Gasdermin D的功能以及细胞焦亡和程序性坏死。该文就近年来Gasdermin D的研究进展展开综述。Pyroptosis is a novel process of programmed inflammatory necrosis,which is closely related to microbial infections and autoimmune diseases.In recent years it has been proved that Gasdermin D is an executive protein of pyroptosis.Cleaved Gasdermin D leads to the formation of pores in cell membrane to induce pyroptosis,and the release of inflammatory factors such as IL-1βand IL-18 aggravates the occurrence of inflammatory responses.With the deepening of Gasdermin D research,it is gradually clear its protein structure and activation sites,which has other activation pathways apart from inducing inflammasome activation.Activation of Gasdermin D does not necessarily mean cell death,even if it could induce the formation of pores in cell membrane and regulation of inflammatory cytokine secretion.These findings offer insight into Gasdermin D function and change our understanding of pyroptosis and programmed necrosis.The recent progress of Gasdermin D is highlighted in this review.

关 键 词：Gasdermin D Gasdermin家族 细胞焦亡 炎症小体 炎症 

分 类 号：R329.24[医药卫生—人体解剖和组织胚胎学] R341[医药卫生—基础医学] R364.5