甲状腺相关眼病中医古籍治法及用药特点探究  

Exploration on the Therapeutic Principles and Medication Regularity of Thyroid Associated Ophthalmopathy in ancient literatures

作　　者：刘新宇 史媚榕 刘祥 冷祥杰 宋姗姗[1] 路雪婧[1,2,3] LIU Xinyu;SHI Meirong;LIU Xiang;LENG Xiangjie;SONG Shanshan;LU Xuejing(Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

机构地区：[1]成都中医药大学,成都610075 [2]中国中医科学院博士后科研流动站,北京100700 [3]视网膜图像技术与慢性血管性疾病防治协同创新中心,成都610075

出　　处：《中国中医眼科杂志》2023年第5期418-422,428,共6页China Journal of Chinese Ophthalmology

基　　金：四川省中医药产业青年创新团队(2017TD0030)。

摘　　要：目的 运用数据挖掘和文献研究的方法探究中医古籍对甲状腺相关眼病(TAO的治法及用药规律。方法 检索博览医书-中医古籍文献数据库、海外中医古籍库、《中华医典》、中国知网古籍数据库中收录录的关于TAO的中医古籍条文,录入Excel,建立文献数据库,进行用药频次、性味、归经等统计分析。结果 (1)一般情况:共纳入古籍条文31条,收录方剂55首,涉及中药67味。累计频次共计402次。频次≥10次的药物共18味,四气以寒性(36.57%)最多,五味中以苦味(58.71%)最多,归经以肝经(58.96%)居多。(2)高频中药使用频次:使用频次排在前5位的分别是防风(7.71%)、当归(5.47%)、赤芍(5.22%)、黄芩(5.22%)、甘草(4.98%)。(3)高频中药功效分类:以解表药(22.22%)、清热药(22.22%)为主。(4)关联规则及聚类分析:相关性最高的前3组药对分别为当归-赤芍,玄参-茺蔚子,芒硝-茺蔚子。(5)聚类分析:可得到3类组方,分别为泻脑汤类方,风药,酒煎散类方。(6)复杂网络分析:古籍处方数据集核心药物包括甘草、防风、当归、赤芍、黄芩、羌活、荆芥等。(7)治法:记载内治法的27篇,外治法21篇,18篇文献内、外治法均有记载。结论 古籍治疗TAO以苦寒清泻为主,多从肝肺论治,上病下取,尤其重视风药和血药的使用。OBJECTIVE To explore the treatment and medication rules of Traditional Chinese Medicine(TCM)in ancient books for thyroid-associated ophthalmopathy(TAO)by using data mining and literature research methods.METHODS Relevant TCM ancient texts related to TAO were retrieved from databases including Zhonghua Yidian,Overseas TCM Classics Library,Browsing Medical Books TCM Ancient Literature Database,and China National Knowledge Infrastructure Ancient Literature Database.The data was entered into Excel and a literature database was established for statistical analysis of medication frequency,properties,and meridians.RESULTS(1)General information:A total of 31 ancient texts and 55 prescriptions were included,involving 67 Chinese medicines with a total of 402 medication frequencies.Eighteen Chinese medicines with a frequency of more than 10 times were identified,and the majority of them(36.57%)were cold in nature,the most common taste was bitter(58.71%),and the most commonly involved meridian was the liver meridian(58.96%).(2)Frequency statistics:The top five Chinese medicines were Saposhnikoviae Radix(7.71%),Angelicae Sinensis Radix(5.47%),Paeoniae Radix Rubra(5.22%),Scutellariae Radix(5.22%),and licorice(4.98%).(3)Effects classification of high-frequency Chinese medicines:The Exterior-Relieving medicine was the most frequently used(22.22%),followed by heat-clearing medicine(22.22%).(4)Association rule analysis and Correlation analysis of high-frequency Chinese medicines:The top three combinations with the highest correlation were"angelica-Radix Paeoniae Rubra""Radix Scrophulariae-Fructus Leonuri""mirabilite-Fructus Leonuri".(5)Cluster analysis:Three types of formula of a decoction were obtained by Cluster analysis.The prescriptions were"XieNao Decoction""Wind Medicine"and"JiuJian Decoction".(6)Complex Network Analysis:The core drugs in the prescription data set of ancient books included licorice,Saposhnikoviae Radix,Angelicae Sinensis Radix,Paeoniae Radix Rubra,Scutellariae Radix,etc.(7)Treatment:There were 27 texts recor

关 键 词：甲状腺相关眼病 鹘眼凝睛 鱼睛不夜 中医古籍 治法方药 数据挖掘 

分 类 号：R276.7[医药卫生—中医五官科学]